The FOXK1-CCDC43 Axis Promotes the Invasion and Metastasis of Colorectal Cancer Cells

Background/Aims: The CCDC43 gene is conserved in human, rhesus monkey, mouse and zebrafish. Bioinformatics studies have demonstrated the abnormal expression of CCDC43 gene in colorectal cancer (CRC). However, the role and molecular mechanism of CCDC43 in CRC remain unknown. Methods: The functional r...

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Veröffentlicht in:	Cellular Physiology and Biochemistry 2019-01, Vol.51 (6), p.2547-2563
Hauptverfasser:	Wang, Jing, Liu, Guangnan, Liu, Mengwei, Xiang, Li, Xiao, Yizhi, Zhu, Huiqiong, Wu, Xiaosheng, Peng, Ying, Zhang, Wenjing, Jiang, Ping, Li, Aimin, Nan, Qingzhen, Chen, Ye, Chen, Chudi, Cheng, Tianming, Liu, Side, Wang, Jide
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer metastasis CCDC43 Cell adhesion & migration Cell cycle Cell Line, Tumor Cell Movement Cell Proliferation Colorectal cancer Colorectal Neoplasms - diagnosis Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Deoxyribonucleic acid Development and progression Disease DNA Epithelial-Mesenchymal Transition Forkhead Transcription Factors - analysis Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism FOXK1 Gastric cancer Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Health aspects Humans Invasion Metastasis MicroRNAs Neoplasm Invasiveness - diagnosis Neoplasm Invasiveness - genetics Neoplasm Invasiveness - pathology Neoplasm Proteins - analysis Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Original Paper Physiological aspects Prognosis Prostate Proteins Transcription factors Up-Regulation
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