BCR/ABL1–like acute lymphoblastic leukemia: How to diagnose and treat?

BCR/ABL1–like acute lymphoblastic leukemia (ALL) accounts for 15% to 30% of B‐lineage ALL, with a peak of incidence occurring in adolescence. This subgroup of patients is characterized by a peculiar transcriptional profile that resembles that of true BCR/ABL1–positive cases, and have a heterogeneous...

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Veröffentlicht in:	Cancer 2019-01, Vol.125 (2), p.194-204
Hauptverfasser:	Chiaretti, Sabina, Messina, Monica, Foà, Robin
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia acute lymphoblastic leukemia (ALL) Adolescents BCR/ABL1–like Clinical trials Cytokine receptors diagnosis Diagnostic systems Gene sequencing Janus kinase Kinases Leukemia Lymphatic leukemia Medical diagnosis Medical prognosis Medical research Mutation Oncology Patients Ph–like prognosis Protein-tyrosine kinase Receptors Subgroups Transcription Tyrosine tyrosine kinase inhibitors (TKIs)
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