In Situ Observation of Amyloid Nucleation and Fibrillation by FastScan Atomic Force Microscopy

Amyloidogenic proteins are key components in various amyloid diseases. The aggregation process and the local structural changes of the toxic species from toxic oligomers to protofibrils and subsequently to mature fibrils are crucial for understanding the molecular mechanism of the amyloidgenic proce...

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Veröffentlicht in:The journal of physical chemistry letters 2019-01, Vol.10 (2), p.214-222
Hauptverfasser: Huang, Qunxing, Wang, Huayi, Gao, Houqian, Cheng, Peng, Zhu, Ling, Wang, Chen, Yang, Yanlian
Format: Artikel
Sprache:eng
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