Engram Cell Excitability State Determines the Efficacy of Memory Retrieval

Animals need to optimize the efficacy of memory retrieval to adapt to environmental circumstances for survival. The recent development of memory engram labeling technology allows a precise investigation of the processes associated with the recall of a specific memory. Here, we show that engram cell...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2019-01, Vol.101 (2), p.274-284.e5
Hauptverfasser:	Pignatelli, Michele, Ryan, Tomás J., Roy, Dheeraj S., Lovett, Chanel, Smith, Lillian M., Muralidhar, Shruti, Tonegawa, Susumu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anisomycin - pharmacology Bacterial Proteins - genetics Behavioral plasticity Channelrhodopsins - genetics Channelrhodopsins - metabolism Conditioning (Psychology) - physiology Data analysis Dentate Gyrus - cytology Doxycycline - pharmacology engram Excitability Freezing Reaction, Cataleptic - drug effects Freezing Reaction, Cataleptic - physiology Gene Expression Regulation - drug effects Gene Expression Regulation - genetics hippocampus Imidazoles - pharmacology Investigations inward rectifier potassium channels Luminescent Proteins - genetics Membrane Potentials - drug effects Membrane Potentials - physiology memory memory access memory retrieval Mental Recall - drug effects Mental Recall - physiology Mice Mice, Transgenic Microscopy, Confocal Neurons - drug effects Neurons - physiology Patch-Clamp Techniques pattern completion pattern separation Phenanthrolines - pharmacology Physiology Potassium Channels, Inwardly Rectifying - genetics Potassium Channels, Inwardly Rectifying - metabolism Protein Synthesis Inhibitors - pharmacology Recall recognition Software Statistical analysis Transduction, Genetic
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