Antiproliferative Effect of a Novel 4,4’-Disulfonyldiarylidenyl Piperidone in Human Colon Cancer Cells
The synthesis and antiproliferative effect of a novel curcumin analog, 4,4’-disulfonyldiarylidenyl piperidone, are reported. The design of the molecule is based on the fusion of an antiproliferative segment, namely diarylidenyl piperidone (DAP), with N -hyroxypyrroline, which is known to metabolical...
Gespeichert in:
| Veröffentlicht in: | Cell biochemistry and biophysics 2019-03, Vol.77 (1), p.61-67 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 67 |
|---|---|
| container_issue | 1 |
| container_start_page | 61 |
| container_title | Cell biochemistry and biophysics |
| container_volume | 77 |
| creator | Prabhat, Anjali M. Kuppusamy, M. Lakshmi Bognár, Balázs Kálai, Tamás Hideg, Kálmán Kuppusamy, Periannan |
| description | The synthesis and antiproliferative effect of a novel curcumin analog, 4,4’-disulfonyldiarylidenyl piperidone, are reported. The design of the molecule is based on the fusion of an antiproliferative segment, namely diarylidenyl piperidone (DAP), with
N
-hyroxypyrroline, which is known to metabolically convert to nitroxide and protect healthy cells. Cellular uptake, metabolic conversion, cytotoxicity and antiproliferative effect of the DAP derivative against HCT-116 human colon cancer cells have been determined. Based on cell viability and proliferation assays as well as western-blot analysis of major transcription factors and inhibitory proteins, it is determined that the DAP compound is cytotoxic by inhibiting cell survival and proliferation pathways. The findings may have important implications in the design and development of effective anticancer agents. |
| doi_str_mv | 10.1007/s12013-018-0862-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2157666943</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2156285533</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-499a4a1d3300a1e63dc9530c1e387d86335461acee56ad8b6fbfd5590b595b643</originalsourceid><addsrcrecordid>eNp1kU1uFDEQhVuIiPzAAdggS2xY4OC_8nQvo0lIkKLAAtaWu10GRx57sLsjZcc1uF5OgkcTQEJiY5fkr17V8-u6l5ydcsZW7yoXjEvKeE9ZrwWFJ90RBxgoE7182mrWAx34AIfdca23jAnBlHrWHUoGIADUUfftLM1hW3IMHoudwx2SC-9xmkn2xJKbfIeRqLfq4cdPeh7qEn1O99EFW-5jcNhq8ilssQSXE5KQyNWysYmsc8zttGnCQtYYY33eHXgbK754vE-6L-8vPq-v6PXHyw_rs2s6yZWYqRoGqyx3UjJmOWrppgEkmzjKfuV6LSUoze2ECNq6ftR-9K5ZZiMMMGolT7o3e91m6vuCdTabUKe2gU2Yl2oEh5XWelCyoa__QW_zUlLbbkdp0QPIHcX31FRyrQW92Zawaf4NZ2YXg9nHYFoMZheDgdbz6lF5GTfo_nT8_vcGiD1Q21P6iuXv6P-r_gJqhJJg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2156285533</pqid></control><display><type>article</type><title>Antiproliferative Effect of a Novel 4,4’-Disulfonyldiarylidenyl Piperidone in Human Colon Cancer Cells</title><source>SpringerNature Journals</source><creator>Prabhat, Anjali M. ; Kuppusamy, M. Lakshmi ; Bognár, Balázs ; Kálai, Tamás ; Hideg, Kálmán ; Kuppusamy, Periannan</creator><creatorcontrib>Prabhat, Anjali M. ; Kuppusamy, M. Lakshmi ; Bognár, Balázs ; Kálai, Tamás ; Hideg, Kálmán ; Kuppusamy, Periannan</creatorcontrib><description>The synthesis and antiproliferative effect of a novel curcumin analog, 4,4’-disulfonyldiarylidenyl piperidone, are reported. The design of the molecule is based on the fusion of an antiproliferative segment, namely diarylidenyl piperidone (DAP), with
N
-hyroxypyrroline, which is known to metabolically convert to nitroxide and protect healthy cells. Cellular uptake, metabolic conversion, cytotoxicity and antiproliferative effect of the DAP derivative against HCT-116 human colon cancer cells have been determined. Based on cell viability and proliferation assays as well as western-blot analysis of major transcription factors and inhibitory proteins, it is determined that the DAP compound is cytotoxic by inhibiting cell survival and proliferation pathways. The findings may have important implications in the design and development of effective anticancer agents.</description><identifier>ISSN: 1085-9195</identifier><identifier>EISSN: 1559-0283</identifier><identifier>DOI: 10.1007/s12013-018-0862-5</identifier><identifier>PMID: 30552554</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Anticancer properties ; Antitumor agents ; Biochemistry ; Biological and Medical Physics ; Biomedical and Life Sciences ; Biophysics ; Biotechnology ; Cancer ; Cell Biology ; Cell proliferation ; Cell survival ; Colon ; Colon cancer ; Colorectal cancer ; Curcumin ; Cytotoxicity ; Life Sciences ; Nitroxide ; Original Paper ; Pharmacology/Toxicology ; Proteins ; Toxicity ; Transcription factors</subject><ispartof>Cell biochemistry and biophysics, 2019-03, Vol.77 (1), p.61-67</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>Cell Biochemistry and Biophysics is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-499a4a1d3300a1e63dc9530c1e387d86335461acee56ad8b6fbfd5590b595b643</citedby><cites>FETCH-LOGICAL-c372t-499a4a1d3300a1e63dc9530c1e387d86335461acee56ad8b6fbfd5590b595b643</cites><orcidid>0000-0002-3214-0660</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12013-018-0862-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12013-018-0862-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30552554$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Prabhat, Anjali M.</creatorcontrib><creatorcontrib>Kuppusamy, M. Lakshmi</creatorcontrib><creatorcontrib>Bognár, Balázs</creatorcontrib><creatorcontrib>Kálai, Tamás</creatorcontrib><creatorcontrib>Hideg, Kálmán</creatorcontrib><creatorcontrib>Kuppusamy, Periannan</creatorcontrib><title>Antiproliferative Effect of a Novel 4,4’-Disulfonyldiarylidenyl Piperidone in Human Colon Cancer Cells</title><title>Cell biochemistry and biophysics</title><addtitle>Cell Biochem Biophys</addtitle><addtitle>Cell Biochem Biophys</addtitle><description>The synthesis and antiproliferative effect of a novel curcumin analog, 4,4’-disulfonyldiarylidenyl piperidone, are reported. The design of the molecule is based on the fusion of an antiproliferative segment, namely diarylidenyl piperidone (DAP), with
N
-hyroxypyrroline, which is known to metabolically convert to nitroxide and protect healthy cells. Cellular uptake, metabolic conversion, cytotoxicity and antiproliferative effect of the DAP derivative against HCT-116 human colon cancer cells have been determined. Based on cell viability and proliferation assays as well as western-blot analysis of major transcription factors and inhibitory proteins, it is determined that the DAP compound is cytotoxic by inhibiting cell survival and proliferation pathways. The findings may have important implications in the design and development of effective anticancer agents.</description><subject>Anticancer properties</subject><subject>Antitumor agents</subject><subject>Biochemistry</subject><subject>Biological and Medical Physics</subject><subject>Biomedical and Life Sciences</subject><subject>Biophysics</subject><subject>Biotechnology</subject><subject>Cancer</subject><subject>Cell Biology</subject><subject>Cell proliferation</subject><subject>Cell survival</subject><subject>Colon</subject><subject>Colon cancer</subject><subject>Colorectal cancer</subject><subject>Curcumin</subject><subject>Cytotoxicity</subject><subject>Life Sciences</subject><subject>Nitroxide</subject><subject>Original Paper</subject><subject>Pharmacology/Toxicology</subject><subject>Proteins</subject><subject>Toxicity</subject><subject>Transcription factors</subject><issn>1085-9195</issn><issn>1559-0283</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU1uFDEQhVuIiPzAAdggS2xY4OC_8nQvo0lIkKLAAtaWu10GRx57sLsjZcc1uF5OgkcTQEJiY5fkr17V8-u6l5ydcsZW7yoXjEvKeE9ZrwWFJ90RBxgoE7182mrWAx34AIfdca23jAnBlHrWHUoGIADUUfftLM1hW3IMHoudwx2SC-9xmkn2xJKbfIeRqLfq4cdPeh7qEn1O99EFW-5jcNhq8ilssQSXE5KQyNWysYmsc8zttGnCQtYYY33eHXgbK754vE-6L-8vPq-v6PXHyw_rs2s6yZWYqRoGqyx3UjJmOWrppgEkmzjKfuV6LSUoze2ECNq6ftR-9K5ZZiMMMGolT7o3e91m6vuCdTabUKe2gU2Yl2oEh5XWelCyoa__QW_zUlLbbkdp0QPIHcX31FRyrQW92Zawaf4NZ2YXg9nHYFoMZheDgdbz6lF5GTfo_nT8_vcGiD1Q21P6iuXv6P-r_gJqhJJg</recordid><startdate>20190315</startdate><enddate>20190315</enddate><creator>Prabhat, Anjali M.</creator><creator>Kuppusamy, M. Lakshmi</creator><creator>Bognár, Balázs</creator><creator>Kálai, Tamás</creator><creator>Hideg, Kálmán</creator><creator>Kuppusamy, Periannan</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3214-0660</orcidid></search><sort><creationdate>20190315</creationdate><title>Antiproliferative Effect of a Novel 4,4’-Disulfonyldiarylidenyl Piperidone in Human Colon Cancer Cells</title><author>Prabhat, Anjali M. ; Kuppusamy, M. Lakshmi ; Bognár, Balázs ; Kálai, Tamás ; Hideg, Kálmán ; Kuppusamy, Periannan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-499a4a1d3300a1e63dc9530c1e387d86335461acee56ad8b6fbfd5590b595b643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Anticancer properties</topic><topic>Antitumor agents</topic><topic>Biochemistry</topic><topic>Biological and Medical Physics</topic><topic>Biomedical and Life Sciences</topic><topic>Biophysics</topic><topic>Biotechnology</topic><topic>Cancer</topic><topic>Cell Biology</topic><topic>Cell proliferation</topic><topic>Cell survival</topic><topic>Colon</topic><topic>Colon cancer</topic><topic>Colorectal cancer</topic><topic>Curcumin</topic><topic>Cytotoxicity</topic><topic>Life Sciences</topic><topic>Nitroxide</topic><topic>Original Paper</topic><topic>Pharmacology/Toxicology</topic><topic>Proteins</topic><topic>Toxicity</topic><topic>Transcription factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prabhat, Anjali M.</creatorcontrib><creatorcontrib>Kuppusamy, M. Lakshmi</creatorcontrib><creatorcontrib>Bognár, Balázs</creatorcontrib><creatorcontrib>Kálai, Tamás</creatorcontrib><creatorcontrib>Hideg, Kálmán</creatorcontrib><creatorcontrib>Kuppusamy, Periannan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell biochemistry and biophysics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prabhat, Anjali M.</au><au>Kuppusamy, M. Lakshmi</au><au>Bognár, Balázs</au><au>Kálai, Tamás</au><au>Hideg, Kálmán</au><au>Kuppusamy, Periannan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiproliferative Effect of a Novel 4,4’-Disulfonyldiarylidenyl Piperidone in Human Colon Cancer Cells</atitle><jtitle>Cell biochemistry and biophysics</jtitle><stitle>Cell Biochem Biophys</stitle><addtitle>Cell Biochem Biophys</addtitle><date>2019-03-15</date><risdate>2019</risdate><volume>77</volume><issue>1</issue><spage>61</spage><epage>67</epage><pages>61-67</pages><issn>1085-9195</issn><eissn>1559-0283</eissn><abstract>The synthesis and antiproliferative effect of a novel curcumin analog, 4,4’-disulfonyldiarylidenyl piperidone, are reported. The design of the molecule is based on the fusion of an antiproliferative segment, namely diarylidenyl piperidone (DAP), with
N
-hyroxypyrroline, which is known to metabolically convert to nitroxide and protect healthy cells. Cellular uptake, metabolic conversion, cytotoxicity and antiproliferative effect of the DAP derivative against HCT-116 human colon cancer cells have been determined. Based on cell viability and proliferation assays as well as western-blot analysis of major transcription factors and inhibitory proteins, it is determined that the DAP compound is cytotoxic by inhibiting cell survival and proliferation pathways. The findings may have important implications in the design and development of effective anticancer agents.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>30552554</pmid><doi>10.1007/s12013-018-0862-5</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-3214-0660</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1085-9195 |
| ispartof | Cell biochemistry and biophysics, 2019-03, Vol.77 (1), p.61-67 |
| issn | 1085-9195 1559-0283 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2157666943 |
| source | SpringerNature Journals |
| subjects | Anticancer properties Antitumor agents Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Biotechnology Cancer Cell Biology Cell proliferation Cell survival Colon Colon cancer Colorectal cancer Curcumin Cytotoxicity Life Sciences Nitroxide Original Paper Pharmacology/Toxicology Proteins Toxicity Transcription factors |
| title | Antiproliferative Effect of a Novel 4,4’-Disulfonyldiarylidenyl Piperidone in Human Colon Cancer Cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T10%3A59%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antiproliferative%20Effect%20of%20a%20Novel%204,4%E2%80%99-Disulfonyldiarylidenyl%20Piperidone%20in%20Human%20Colon%20Cancer%20Cells&rft.jtitle=Cell%20biochemistry%20and%20biophysics&rft.au=Prabhat,%20Anjali%20M.&rft.date=2019-03-15&rft.volume=77&rft.issue=1&rft.spage=61&rft.epage=67&rft.pages=61-67&rft.issn=1085-9195&rft.eissn=1559-0283&rft_id=info:doi/10.1007/s12013-018-0862-5&rft_dat=%3Cproquest_cross%3E2156285533%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2156285533&rft_id=info:pmid/30552554&rfr_iscdi=true |