Molecular modulators of celastrol as the keystones for its diverse pharmacological activities

[Display omitted] •Celastrol exhibits curative properties in the treatment of several diseases.•Celastrol modulates through a variety of molecular targets in the system.•Clinical trials have demonstrated therapeutic effectiveness of celastrol.•The therapeutic properties of celastrol circumvent its t...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2019-01, Vol.109, p.1785-1792
Hauptverfasser:	Ng, Sin Wi, Chan, Yinghan, Chellappan, Dinesh Kumar, Madheswaran, Thiagarajan, Zeeshan, Farrukh, Chan, Yik Lung, Collet, Trudi, Gupta, Gaurav, Oliver, Brian G., Wark, Peter, Hansbro, Nicole, Hsu, Alan, Hansbro, Philip Michael, Dua, Kamal, Panneerselvam, Jithendra
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-cancer Anti-diabetic Anti-inflammatory Anti-obesity Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - metabolism Biological Products - chemistry Biological Products - isolation & purification Biological Products - therapeutic use Celastrol Drug Discovery - methods Drug Discovery - trends Humans Inflammation - drug therapy Inflammation - metabolism Metabolic Diseases - drug therapy Metabolic Diseases - metabolism Molecular modulators Neuroprotective Plants, Medicinal Tripterygium Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - therapeutic use
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