A CCR4 antagonist ameliorates atopic dermatitis-like skin lesions induced by dibutyl phthalate and a hydrogel patch containing ovalbumin

[Display omitted] •Topical application of OVA and DBP increased TSLP, CCL17, and CCL22 expression.•Topical application of OVA and DBP enhanced Th2 cell infiltration in the skin.•Topical application of OVA and DBP induced acute AD-like skin lesions.•Cutaneous administration of a CCR4 antagonist ameli...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2019-01, Vol.109, p.1437-1444
Hauptverfasser:	Matsuo, Kazuhiko, Hatanaka, Shota, Kimura, Yuta, Hara, Yuta, Nishiwaki, Keiji, Quan, Ying-Shu, Kamiyama, Fumio, Oiso, Naoki, Kawada, Akira, Kabashima, Kenji, Nakayama, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Atopic dermatitis CCL17 CCL22 CCR4 Dibutyl phthalate TSLP
Online-Zugang:	Volltext
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