Preparation of hydroxylated lecithin complexed iodine/carboxymethyl chitosan/sodium alginate composite membrane by microwave drying and its applications in infected burn wound treatment

•Iodine was complexed with HL to improve its stability and complexing efficiency.•HLI/CMCS/SA composite membrane was prepared via microwave drying method.•The membrane showed excellent comprehensive properties.•The membrane exhibited pH controllable iodine release and antibacterial properties.•It ex...

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Veröffentlicht in:Carbohydrate polymers 2019-02, Vol.206, p.435-445
Hauptverfasser: Chen, Yu, Qiu, Haiying, Dong, Miheng, Cheng, Bin, Jin, Yiguang, Tong, Zongrui, Li, Puwang, Li, Sidong, Yang, Ziming
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container_end_page 445
container_issue
container_start_page 435
container_title Carbohydrate polymers
container_volume 206
creator Chen, Yu
Qiu, Haiying
Dong, Miheng
Cheng, Bin
Jin, Yiguang
Tong, Zongrui
Li, Puwang
Li, Sidong
Yang, Ziming
description •Iodine was complexed with HL to improve its stability and complexing efficiency.•HLI/CMCS/SA composite membrane was prepared via microwave drying method.•The membrane showed excellent comprehensive properties.•The membrane exhibited pH controllable iodine release and antibacterial properties.•It exhibited high repairing efficiency for seawater immersed wound infection. Improving the antibacterial properties of membrane wound dressings of natural polymers is crucial. Iodine is an important safe inorganic antibacterial agent, but was confined in the composition with polymer membranes due to the challenges of homogeneity and stability during drying. In the present work, iodine was complexed with hydroxylated lecithin (HL) to improve its stability and complexing efficiency for the composition with carboxymethly chitosan/sodium alginate. With the aid of microwave drying, hydroxylated lecithin complexed iodine/carboxymethly chitosan/sodium alginate (HLI/CMCS/SA) composite membranes with homogeneously distributions of HLI, high contents of activated iodine, good mechanical and swelling properties, proper water vapor permeability, pH controllable iodine release and excellent antibacterial properties were prepared. The composite membranes exhibited high repairing efficiencies for the infection of a rat model of the seawater immersed wound infection of deep partial-thickness burns. This novel antibacterial composite membrane can be potentially used as a high performance wound dressing for treating and repairing open trauma infections.
doi_str_mv 10.1016/j.carbpol.2018.10.068
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Improving the antibacterial properties of membrane wound dressings of natural polymers is crucial. Iodine is an important safe inorganic antibacterial agent, but was confined in the composition with polymer membranes due to the challenges of homogeneity and stability during drying. In the present work, iodine was complexed with hydroxylated lecithin (HL) to improve its stability and complexing efficiency for the composition with carboxymethly chitosan/sodium alginate. With the aid of microwave drying, hydroxylated lecithin complexed iodine/carboxymethly chitosan/sodium alginate (HLI/CMCS/SA) composite membranes with homogeneously distributions of HLI, high contents of activated iodine, good mechanical and swelling properties, proper water vapor permeability, pH controllable iodine release and excellent antibacterial properties were prepared. The composite membranes exhibited high repairing efficiencies for the infection of a rat model of the seawater immersed wound infection of deep partial-thickness burns. This novel antibacterial composite membrane can be potentially used as a high performance wound dressing for treating and repairing open trauma infections.</description><identifier>ISSN: 0144-8617</identifier><identifier>EISSN: 1879-1344</identifier><identifier>DOI: 10.1016/j.carbpol.2018.10.068</identifier><identifier>PMID: 30553343</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Carboxymethyl chitosan ; Hydroxylated lecithin ; Iodine ; Membrane ; Sodium alginate ; Wound dressing</subject><ispartof>Carbohydrate polymers, 2019-02, Vol.206, p.435-445</ispartof><rights>2018 Elsevier Ltd</rights><rights>Copyright © 2018 Elsevier Ltd. 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Improving the antibacterial properties of membrane wound dressings of natural polymers is crucial. Iodine is an important safe inorganic antibacterial agent, but was confined in the composition with polymer membranes due to the challenges of homogeneity and stability during drying. In the present work, iodine was complexed with hydroxylated lecithin (HL) to improve its stability and complexing efficiency for the composition with carboxymethly chitosan/sodium alginate. With the aid of microwave drying, hydroxylated lecithin complexed iodine/carboxymethly chitosan/sodium alginate (HLI/CMCS/SA) composite membranes with homogeneously distributions of HLI, high contents of activated iodine, good mechanical and swelling properties, proper water vapor permeability, pH controllable iodine release and excellent antibacterial properties were prepared. The composite membranes exhibited high repairing efficiencies for the infection of a rat model of the seawater immersed wound infection of deep partial-thickness burns. This novel antibacterial composite membrane can be potentially used as a high performance wound dressing for treating and repairing open trauma infections.</description><subject>Carboxymethyl chitosan</subject><subject>Hydroxylated lecithin</subject><subject>Iodine</subject><subject>Membrane</subject><subject>Sodium alginate</subject><subject>Wound dressing</subject><issn>0144-8617</issn><issn>1879-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqFUU1v1DAUjBCIbgs_AeQjl-zaieNkTwhVBSpVggOcLcd-7nrlj2A7bfPT-Hc43YUrvth6b-bNG09VvSN4SzBhu-NWijhOwW4bTIZS22I2vKg2ZOj3NWkpfVltMKG0HhjpL6rLlI64HEbw6-qixV3XtrTdVL-_R5hEFNkEj4JGh0XF8LRYkUEhC9Lkg_FIBjdZeColE5TxsFu1C8xBPiwWyYPJIQm_S6U7OyTsvfFlwjMvJFNeDtwYhQc0LsgZGcOjeACk4mL8PRK-DM4JiWmyRj7vklCRNV6DXBcZ5-jRY5gLLkcQ2YHPb6pXWtgEb8_3VfXz882P66_13bcvt9ef7mpJcZPrAajWhCjWK9FR3TGhqG51IwVpSCP2e6WH_ShBj9CyTja9pM3QEaZHPUjFWHtVfTjNnWL4NUPK3JkkwdriJsyJN6TrGaN03xRod4IWfylF0HyKxom4cIL5mho_8nNqfE1tLZfUCu_9WWIeHah_rL8xFcDHEwCK0QcDkSdpwEtQJpYf4iqY_0j8ATmhsxQ</recordid><startdate>20190215</startdate><enddate>20190215</enddate><creator>Chen, Yu</creator><creator>Qiu, Haiying</creator><creator>Dong, Miheng</creator><creator>Cheng, Bin</creator><creator>Jin, Yiguang</creator><creator>Tong, Zongrui</creator><creator>Li, Puwang</creator><creator>Li, Sidong</creator><creator>Yang, Ziming</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3528-1397</orcidid></search><sort><creationdate>20190215</creationdate><title>Preparation of hydroxylated lecithin complexed iodine/carboxymethyl chitosan/sodium alginate composite membrane by microwave drying and its applications in infected burn wound treatment</title><author>Chen, Yu ; Qiu, Haiying ; Dong, Miheng ; Cheng, Bin ; Jin, Yiguang ; Tong, Zongrui ; Li, Puwang ; Li, Sidong ; Yang, Ziming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-8e4ff11d67da54f56ad4f3f2ca1212a99df89bcefbe365c27c428516fbf8cd663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Carboxymethyl chitosan</topic><topic>Hydroxylated lecithin</topic><topic>Iodine</topic><topic>Membrane</topic><topic>Sodium alginate</topic><topic>Wound dressing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Yu</creatorcontrib><creatorcontrib>Qiu, Haiying</creatorcontrib><creatorcontrib>Dong, Miheng</creatorcontrib><creatorcontrib>Cheng, Bin</creatorcontrib><creatorcontrib>Jin, Yiguang</creatorcontrib><creatorcontrib>Tong, Zongrui</creatorcontrib><creatorcontrib>Li, Puwang</creatorcontrib><creatorcontrib>Li, Sidong</creatorcontrib><creatorcontrib>Yang, Ziming</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Carbohydrate polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Yu</au><au>Qiu, Haiying</au><au>Dong, Miheng</au><au>Cheng, Bin</au><au>Jin, Yiguang</au><au>Tong, Zongrui</au><au>Li, Puwang</au><au>Li, Sidong</au><au>Yang, Ziming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation of hydroxylated lecithin complexed iodine/carboxymethyl chitosan/sodium alginate composite membrane by microwave drying and its applications in infected burn wound treatment</atitle><jtitle>Carbohydrate polymers</jtitle><addtitle>Carbohydr Polym</addtitle><date>2019-02-15</date><risdate>2019</risdate><volume>206</volume><spage>435</spage><epage>445</epage><pages>435-445</pages><issn>0144-8617</issn><eissn>1879-1344</eissn><abstract>•Iodine was complexed with HL to improve its stability and complexing efficiency.•HLI/CMCS/SA composite membrane was prepared via microwave drying method.•The membrane showed excellent comprehensive properties.•The membrane exhibited pH controllable iodine release and antibacterial properties.•It exhibited high repairing efficiency for seawater immersed wound infection. Improving the antibacterial properties of membrane wound dressings of natural polymers is crucial. Iodine is an important safe inorganic antibacterial agent, but was confined in the composition with polymer membranes due to the challenges of homogeneity and stability during drying. In the present work, iodine was complexed with hydroxylated lecithin (HL) to improve its stability and complexing efficiency for the composition with carboxymethly chitosan/sodium alginate. With the aid of microwave drying, hydroxylated lecithin complexed iodine/carboxymethly chitosan/sodium alginate (HLI/CMCS/SA) composite membranes with homogeneously distributions of HLI, high contents of activated iodine, good mechanical and swelling properties, proper water vapor permeability, pH controllable iodine release and excellent antibacterial properties were prepared. 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subjects Carboxymethyl chitosan
Hydroxylated lecithin
Iodine
Membrane
Sodium alginate
Wound dressing
title Preparation of hydroxylated lecithin complexed iodine/carboxymethyl chitosan/sodium alginate composite membrane by microwave drying and its applications in infected burn wound treatment
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