Assessing the risk of drug crystallization in vivo

Low intrinsic solubility leading to poor oral bioavailability is a common challenge in drug discovery that can often be overcome by formulation strategies, however, it remains a potential limitation that can pose challenges for early risk assessment and represent a significant obstacle to drug devel...

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Veröffentlicht in:	Journal of pharmacological and toxicological methods 2019-03, Vol.96, p.1-8
Hauptverfasser:	Ruepp, Stefan, Janovitz, Evan, Brodie, Thomas, White, Randy, Santella, Joseph, Hynes, John, Carman, Julie, Pan, Duohai, Wu, Yang, Hanumegowda, Umesh, Gemzik, Brian, Megill, John, DiPiero, Janet, Drexler, Dieter, Su, Ching-Chiang, Hageman, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Birefringent crystal Granulomatous inflammation IRAK4 Methods Microscopy Raman spectroscopy
Online-Zugang:	Volltext
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