A hit deconstruction approach for the discovery of fetal hemoglobin inducers

[Display omitted] •Benzoxaborole compounds can be optimized by deconstruction and reconstruction.•The compounds have been optimized for cellular HbF induction, solubility, and PK.•The optimized compounds inhibit key RNA processing proteins. Beta-hemoglobinopathies such as sickle cell disease represe...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2018-12, Vol.28 (23-24), p.3676-3680
Hauptverfasser:	Benowitz, Andrew B., Eberl, H. Christian, Erickson-Miller, Connie L., Gilmartin, Aidan G., Gore, Elizabeth R., Montoute, Monica N., Wu, Zining
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzoxaborole Beta-thalassemia CPSF Fetal hemoglobin Sickle cell anemia
Online-Zugang:	Volltext
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