Human ESC-Derived Chimeric Mouse Models of Huntington’s Disease Reveal Cell-Intrinsic Defects in Glial Progenitor Cell Differentiation

Huntington’s disease (HD) is characterized by hypomyelination and neuronal loss. To assess the basis for myelin loss in HD, we generated bipotential glial progenitor cells (GPCs) from human embryonic stem cells (hESCs) derived from mutant Huntingtin (mHTT) embryos or normal controls and performed RN...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell stem cell 2019-01, Vol.24 (1), p.107-122.e7
Hauptverfasser:	Osipovitch, Mikhail, Asenjo Martinez, Andrea, Mariani, John N., Cornwell, Adam, Dhaliwal, Simrat, Zou, Lisa, Chandler-Militello, Devin, Wang, Su, Li, Xiaojie, Benraiss, Sarah-Jehanne, Agate, Robert, Lampp, Andrea, Benraiss, Abdellatif, Windrem, Martha S., Goldman, Steven A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals astrocyte Astrocytes - metabolism Astrocytes - pathology Cell Differentiation Chimera chimeric mouse Demyelinating Diseases - genetics Demyelinating Diseases - metabolism Demyelinating Diseases - pathology Disease Models, Animal embryonic stem cell glia Human Embryonic Stem Cells - metabolism Human Embryonic Stem Cells - pathology Humans Huntingtin Protein - genetics Huntington Disease - genetics Huntington Disease - metabolism Huntington Disease - pathology Huntington’s disease Mice Mutation myelin MYRF neurodegenerative disease Neurogenesis Neuroglia - metabolism Neuroglia - pathology oligodendrocyte Stem Cells - metabolism Stem Cells - pathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!