Phenotypic Plasticity: Driver of Cancer Initiation, Progression, and Therapy Resistance

Our traditional understanding of phenotypic plasticity in adult somatic cells comprises dedifferentiation and transdifferentiation in the context of tissue regeneration or wound healing. Although dedifferentiation is central to tissue repair and stemness, this process inherently carries the risk of...

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Veröffentlicht in:	Cell stem cell 2019-01, Vol.24 (1), p.65-78
Hauptverfasser:	Gupta, Piyush B., Pastushenko, Ievgenia, Skibinski, Adam, Blanpain, Cedric, Kuperwasser, Charlotte
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological Animals cancer Disease Progression Drug Resistance, Neoplasm epithelial to mesenchymal transition Epithelial-Mesenchymal Transition Humans Neoplasms - drug therapy Neoplasms - pathology Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - pathology plasticity therapy resistance
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