Quality assessment of Ki67 staining using cell line proliferation index and stain intensity features

Breast cancer is the most frequent cancer among women worldwide. Ki67 can be used as an immunohistochemical pseudo marker for cell proliferation to determine how aggressive the cancer is and thereby the treatment of the patient. No standard Ki67 staining protocol exists, resulting in inter‐laborator...

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Veröffentlicht in:	Cytometry. Part A 2019-04, Vol.95 (4), p.381-388
Hauptverfasser:	Lanng, Mathias Buus, Møller, Cecilie Brochdorff, Andersen, Anne‐Sofie Hendrup, Pálsdóttir, Ásgerður Arna, Røge, Rasmus, Østergaard, Lasse Riis, Jørgensen, Alex Skovsbo
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Biotechnology Breast cancer Cancer Cell proliferation cell segmentation Cytometry Feature extraction image analysis Ki67 Nuclei Nuclei (cytology) Patients proliferation index Quality assessment Quality control Regression models Sensitivity stain quality assessment Staining Stains & staining Statistical analysis
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