Endemicity of the High-Risk Clone Klebsiella pneumoniae ST340 Coproducing QnrB, CTX-M-15, and KPC-2 in a Brazilian Hospital
The dissemination of multiresistant Klebsiella pneumoniae carbapenemase (KPC)-2-producing Klebsiella pneumoniae isolates belonging to international high-risk clones poses a major health care threat. In this study, 48 nonduplicated, carbapenem-resistant K. pneumoniae isolated from 2011 to 2014 in a t...
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| Veröffentlicht in: | Microbial drug resistance (Larchmont, N.Y.) N.Y.), 2019-05, Vol.25 (4), p.528-537 |
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| container_title | Microbial drug resistance (Larchmont, N.Y.) |
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| creator | Tolentino, Fernanda Modesto Bueno, Maria Fernanda Campagnari Franscisco, Gabriela Rodrigues Barcelos, Diego Diniz de Paula Lobo, Suzana Margareth Tomaz, Francieli Maira Moreira Batista da Silva, Natal Santos de Andrade, Leonardo Neves Casella, Tiago Darini, Ana Lucia da Costa Polotto, Milena de Oliveira Garcia, Doroti Nogueira, Mara Correa Lelles |
| description | The dissemination of multiresistant
Klebsiella pneumoniae
carbapenemase (KPC)-2-producing
Klebsiella pneumoniae
isolates belonging to international high-risk clones poses a major health care threat. In this study, 48 nonduplicated, carbapenem-resistant
K. pneumoniae
isolated from 2011 to 2014 in a tertiary hospital were investigated. The
bla
KPC-2
gene was the only determinant for carbapenem resistance. The
bla
CTX-M-15
gene was the main determinant for the production of extended-spectrum beta-lactamase (ESBL), whereas
aph(3′)-Ia
and
qnrB
were the most common genes associated with resistance to aminoglycosides and quinolones, respectively. Nine different sequence types (STs) were identified. The most common was ST340. Molecular typing by enterobacterial repetitive intergenic consensus-PCR placed 48 strains among 10 different clusters. In the studied hospital, the high-risk clone of KPC-2-producing
K. pneumoniae
ST340, harboring genes that codify aminoglycoside modifying enzymes, QnrB and CTX-M-15 plus CTXM-2-type ESBLs, is disseminated and acts as a major agent of infections in critically ill patients. |
| doi_str_mv | 10.1089/mdr.2018.0006 |
| format | Article |
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Klebsiella pneumoniae
carbapenemase (KPC)-2-producing
Klebsiella pneumoniae
isolates belonging to international high-risk clones poses a major health care threat. In this study, 48 nonduplicated, carbapenem-resistant
K. pneumoniae
isolated from 2011 to 2014 in a tertiary hospital were investigated. The
bla
KPC-2
gene was the only determinant for carbapenem resistance. The
bla
CTX-M-15
gene was the main determinant for the production of extended-spectrum beta-lactamase (ESBL), whereas
aph(3′)-Ia
and
qnrB
were the most common genes associated with resistance to aminoglycosides and quinolones, respectively. Nine different sequence types (STs) were identified. The most common was ST340. Molecular typing by enterobacterial repetitive intergenic consensus-PCR placed 48 strains among 10 different clusters. In the studied hospital, the high-risk clone of KPC-2-producing
K. pneumoniae
ST340, harboring genes that codify aminoglycoside modifying enzymes, QnrB and CTX-M-15 plus CTXM-2-type ESBLs, is disseminated and acts as a major agent of infections in critically ill patients.</description><identifier>ISSN: 1076-6294</identifier><identifier>EISSN: 1931-8448</identifier><identifier>DOI: 10.1089/mdr.2018.0006</identifier><identifier>PMID: 30543470</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc., publishers</publisher><subject>Aminoglycosides ; Carbapenemase ; Cloning ; Codification ; Epidemiology ; Genes ; Klebsiella ; Klebsiella pneumoniae ; Quinolones ; Risk ; Typing ; β Lactamase</subject><ispartof>Microbial drug resistance (Larchmont, N.Y.), 2019-05, Vol.25 (4), p.528-537</ispartof><rights>2019, Mary Ann Liebert, Inc., publishers</rights><rights>Copyright Mary Ann Liebert, Inc. May 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-c33126ffbc7f3a9106225ac44a7c4cee10eb3125971d3db3c4b1da644608698a3</citedby><cites>FETCH-LOGICAL-c365t-c33126ffbc7f3a9106225ac44a7c4cee10eb3125971d3db3c4b1da644608698a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30543470$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tolentino, Fernanda Modesto</creatorcontrib><creatorcontrib>Bueno, Maria Fernanda Campagnari</creatorcontrib><creatorcontrib>Franscisco, Gabriela Rodrigues</creatorcontrib><creatorcontrib>Barcelos, Diego Diniz de Paula</creatorcontrib><creatorcontrib>Lobo, Suzana Margareth</creatorcontrib><creatorcontrib>Tomaz, Francieli Maira Moreira Batista</creatorcontrib><creatorcontrib>da Silva, Natal Santos</creatorcontrib><creatorcontrib>de Andrade, Leonardo Neves</creatorcontrib><creatorcontrib>Casella, Tiago</creatorcontrib><creatorcontrib>Darini, Ana Lucia da Costa</creatorcontrib><creatorcontrib>Polotto, Milena</creatorcontrib><creatorcontrib>de Oliveira Garcia, Doroti</creatorcontrib><creatorcontrib>Nogueira, Mara Correa Lelles</creatorcontrib><title>Endemicity of the High-Risk Clone Klebsiella pneumoniae ST340 Coproducing QnrB, CTX-M-15, and KPC-2 in a Brazilian Hospital</title><title>Microbial drug resistance (Larchmont, N.Y.)</title><addtitle>Microb Drug Resist</addtitle><description>The dissemination of multiresistant
Klebsiella pneumoniae
carbapenemase (KPC)-2-producing
Klebsiella pneumoniae
isolates belonging to international high-risk clones poses a major health care threat. In this study, 48 nonduplicated, carbapenem-resistant
K. pneumoniae
isolated from 2011 to 2014 in a tertiary hospital were investigated. The
bla
KPC-2
gene was the only determinant for carbapenem resistance. The
bla
CTX-M-15
gene was the main determinant for the production of extended-spectrum beta-lactamase (ESBL), whereas
aph(3′)-Ia
and
qnrB
were the most common genes associated with resistance to aminoglycosides and quinolones, respectively. Nine different sequence types (STs) were identified. The most common was ST340. Molecular typing by enterobacterial repetitive intergenic consensus-PCR placed 48 strains among 10 different clusters. In the studied hospital, the high-risk clone of KPC-2-producing
K. pneumoniae
ST340, harboring genes that codify aminoglycoside modifying enzymes, QnrB and CTX-M-15 plus CTXM-2-type ESBLs, is disseminated and acts as a major agent of infections in critically ill patients.</description><subject>Aminoglycosides</subject><subject>Carbapenemase</subject><subject>Cloning</subject><subject>Codification</subject><subject>Epidemiology</subject><subject>Genes</subject><subject>Klebsiella</subject><subject>Klebsiella pneumoniae</subject><subject>Quinolones</subject><subject>Risk</subject><subject>Typing</subject><subject>β Lactamase</subject><issn>1076-6294</issn><issn>1931-8448</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqF0btv1TAUBnALgegDRlZkiYWhvvUrTjK2UelFLeJ1kdgsxzlp3Sb2rZ0Mbf_5OrqFgYXFtqyfPp2jD6F3jK4YrerjsYsrTlm1opSqF2if1YKRSsrqZX7TUhHFa7mHDlK6yaJgSrxGe4IWUsiS7qPHM9_B6Kyb7nHo8XQNeO2urskPl25xMwQP-GKANjkYBoO3HuYxeGcA_9wISXETtjF0s3X-Cn_38fQIN5vf5AthxRE2vsMX3xrCsfPY4NNoHtzgjMfrkLZuMsMb9Ko3Q4K3z_ch-vXpbNOsyeXX88_NySWxQhVTPgXjqu9bW_bC1IwqzgtjpTSllRaAUWizKOqSdaJrhZUt64ySUtFK1ZURh-jjLjfPejdDmvTokl0W8hDmpDkrSlVwRmWmH_6hN2GOPk-nOResEpzzOiuyUzaGlCL0ehvdaOK9ZlQvrejcil5a0Usr2b9_Tp3bEbq_-k8NGYgdWL6N94ODFuL0n9gnBxmVow</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>Tolentino, Fernanda Modesto</creator><creator>Bueno, Maria Fernanda Campagnari</creator><creator>Franscisco, Gabriela Rodrigues</creator><creator>Barcelos, Diego Diniz de Paula</creator><creator>Lobo, Suzana Margareth</creator><creator>Tomaz, Francieli Maira Moreira Batista</creator><creator>da Silva, Natal Santos</creator><creator>de Andrade, Leonardo Neves</creator><creator>Casella, Tiago</creator><creator>Darini, Ana Lucia da Costa</creator><creator>Polotto, Milena</creator><creator>de Oliveira Garcia, Doroti</creator><creator>Nogueira, Mara Correa Lelles</creator><general>Mary Ann Liebert, Inc., publishers</general><general>Mary Ann Liebert, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20190501</creationdate><title>Endemicity of the High-Risk Clone Klebsiella pneumoniae ST340 Coproducing QnrB, CTX-M-15, and KPC-2 in a Brazilian Hospital</title><author>Tolentino, Fernanda Modesto ; Bueno, Maria Fernanda Campagnari ; Franscisco, Gabriela Rodrigues ; Barcelos, Diego Diniz de Paula ; Lobo, Suzana Margareth ; Tomaz, Francieli Maira Moreira Batista ; da Silva, Natal Santos ; de Andrade, Leonardo Neves ; Casella, Tiago ; Darini, Ana Lucia da Costa ; Polotto, Milena ; de Oliveira Garcia, Doroti ; Nogueira, Mara Correa Lelles</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-c33126ffbc7f3a9106225ac44a7c4cee10eb3125971d3db3c4b1da644608698a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aminoglycosides</topic><topic>Carbapenemase</topic><topic>Cloning</topic><topic>Codification</topic><topic>Epidemiology</topic><topic>Genes</topic><topic>Klebsiella</topic><topic>Klebsiella pneumoniae</topic><topic>Quinolones</topic><topic>Risk</topic><topic>Typing</topic><topic>β Lactamase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tolentino, Fernanda Modesto</creatorcontrib><creatorcontrib>Bueno, Maria Fernanda Campagnari</creatorcontrib><creatorcontrib>Franscisco, Gabriela Rodrigues</creatorcontrib><creatorcontrib>Barcelos, Diego Diniz de Paula</creatorcontrib><creatorcontrib>Lobo, Suzana Margareth</creatorcontrib><creatorcontrib>Tomaz, Francieli Maira Moreira Batista</creatorcontrib><creatorcontrib>da Silva, Natal Santos</creatorcontrib><creatorcontrib>de Andrade, Leonardo Neves</creatorcontrib><creatorcontrib>Casella, Tiago</creatorcontrib><creatorcontrib>Darini, Ana Lucia da Costa</creatorcontrib><creatorcontrib>Polotto, Milena</creatorcontrib><creatorcontrib>de Oliveira Garcia, Doroti</creatorcontrib><creatorcontrib>Nogueira, Mara Correa Lelles</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Microbial drug resistance (Larchmont, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tolentino, Fernanda Modesto</au><au>Bueno, Maria Fernanda Campagnari</au><au>Franscisco, Gabriela Rodrigues</au><au>Barcelos, Diego Diniz de Paula</au><au>Lobo, Suzana Margareth</au><au>Tomaz, Francieli Maira Moreira Batista</au><au>da Silva, Natal Santos</au><au>de Andrade, Leonardo Neves</au><au>Casella, Tiago</au><au>Darini, Ana Lucia da Costa</au><au>Polotto, Milena</au><au>de Oliveira Garcia, Doroti</au><au>Nogueira, Mara Correa Lelles</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endemicity of the High-Risk Clone Klebsiella pneumoniae ST340 Coproducing QnrB, CTX-M-15, and KPC-2 in a Brazilian Hospital</atitle><jtitle>Microbial drug resistance (Larchmont, N.Y.)</jtitle><addtitle>Microb Drug Resist</addtitle><date>2019-05-01</date><risdate>2019</risdate><volume>25</volume><issue>4</issue><spage>528</spage><epage>537</epage><pages>528-537</pages><issn>1076-6294</issn><eissn>1931-8448</eissn><abstract>The dissemination of multiresistant
Klebsiella pneumoniae
carbapenemase (KPC)-2-producing
Klebsiella pneumoniae
isolates belonging to international high-risk clones poses a major health care threat. In this study, 48 nonduplicated, carbapenem-resistant
K. pneumoniae
isolated from 2011 to 2014 in a tertiary hospital were investigated. The
bla
KPC-2
gene was the only determinant for carbapenem resistance. The
bla
CTX-M-15
gene was the main determinant for the production of extended-spectrum beta-lactamase (ESBL), whereas
aph(3′)-Ia
and
qnrB
were the most common genes associated with resistance to aminoglycosides and quinolones, respectively. Nine different sequence types (STs) were identified. The most common was ST340. Molecular typing by enterobacterial repetitive intergenic consensus-PCR placed 48 strains among 10 different clusters. In the studied hospital, the high-risk clone of KPC-2-producing
K. pneumoniae
ST340, harboring genes that codify aminoglycoside modifying enzymes, QnrB and CTX-M-15 plus CTXM-2-type ESBLs, is disseminated and acts as a major agent of infections in critically ill patients.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc., publishers</pub><pmid>30543470</pmid><doi>10.1089/mdr.2018.0006</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1076-6294 |
| ispartof | Microbial drug resistance (Larchmont, N.Y.), 2019-05, Vol.25 (4), p.528-537 |
| issn | 1076-6294 1931-8448 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2157652104 |
| source | Alma/SFX Local Collection |
| subjects | Aminoglycosides Carbapenemase Cloning Codification Epidemiology Genes Klebsiella Klebsiella pneumoniae Quinolones Risk Typing β Lactamase |
| title | Endemicity of the High-Risk Clone Klebsiella pneumoniae ST340 Coproducing QnrB, CTX-M-15, and KPC-2 in a Brazilian Hospital |
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