Clinical significance and peculiarities of succinate dehydrogenase B and hypoxia inducible factor 1α expression in parasympathetic versus sympathetic paragangliomas

Background Succinate dehydrogenase subunit B (SDHB) immunohistochemistry was considered a valuable tool to identify patients with inherited paraganglioma/pheochromocytoma (PGL/PCC). However, previous studies jointly analyzed 2 related but clinically distinct entities, parasympathetic head and neck p...

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Veröffentlicht in:	Head & neck 2019-01, Vol.41 (1), p.79-91
Hauptverfasser:	Bernardo‐Castiñeira, Cristóbal, Sáenz‐de‐Santa‐María, Inés, Valdés, Nuria, Astudillo, Aurora, Balbín, Milagros, Pitiot, Ana S., Jiménez‐Fonseca, Paula, Scola, Bartolomé, Tena, Isabel, Molina‐Garrido, María‐José, Sevilla, María‐Agustina, Beristein, Elena, Forga, Lluís, Villabona, Carles, Oriola, Josep, Halperin, Irene, Suarez, Carlos, Chiara, María‐Dolores
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Gland Neoplasms - genetics Adrenal Gland Neoplasms - metabolism Adult Biomarkers Biomarkers, Tumor - metabolism Clinical significance Dehydrogenases Female Genetic screening Germ-Line Mutation Head and neck Head and Neck Neoplasms - genetics Head and Neck Neoplasms - metabolism head and neck paragangliomas Humans Hypoxia hypoxia inducible factor (HIF) Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Immunohistochemistry Male Mutation Neuroendocrine tumors Paraganglioma Paraganglioma, Extra-Adrenal - genetics Paraganglioma, Extra-Adrenal - metabolism Parasympathetic nervous system Pheochromocytoma Pheochromocytoma - genetics Pheochromocytoma - metabolism Predictive Value of Tests Sensitivity and Specificity Succinate dehydrogenase Succinate Dehydrogenase - genetics Succinate Dehydrogenase - metabolism succinate dehydrogenase subunit A (SDHA) succinate dehydrogenase subunit B (SDHB) sympathetic paragangliomas Tumors
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