Sertraline ameliorates inflammation in CUMS mice and inhibits TNF-α-induced inflammation in microglia cells

Evidence indicates that inflammation plays a crucial role in depression. Therefore, new antidepressants might be identified by screening drugs for their anti-inflammatory actions. Sertraline hydrochloride (SERT), a widely used antidepressant, has anti-inflammatory effects in clinical studies, but th...

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Veröffentlicht in:	International immunopharmacology 2019-02, Vol.67, p.119-128
Hauptverfasser:	Lu, Ying, Xu, Xiang, Jiang, Tong, Jin, Lan, Zhao, Xu-Dong, Cheng, Jia-Hui, Jin, Xue-Jun, Ma, Juan, Piao, Hu-Nan, Piao, Lian-Xun
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Antidepressants Chronic unpredictable mild stress (CUMS) Cytokines Depression Drug screening IL-1β In vivo methods and tests Inflammation Interleukins Lymphocytes B Mental depression Mice Microglia Molecular biology NF-κB protein Nitric oxide Nitric-oxide synthase Nuclear factor-κB (NF-κB) Nuclear transport Phosphorylation R&D Research & development Rodents Sertraline Serum levels Signal transduction Signaling Transaminase Translocation Tumor necrosis factor receptors Tumor necrosis factor-TNF Tumor necrosis factor-α
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