Ecdysis triggering hormone receptors regulate male courtship behavior via antennal lobe interneurons in Drosophila
•ETHR silencing in antennal lobe interneurons elevates male-male courtship.•ETHR silencing in fruitless neurons increases male-male courtship.•JH deficiency does not cause elevated male-male courtship.•Genes for axon guidanceand chemosensory functions are differentially expressed.•ETHR signaling reg...
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| Veröffentlicht in: | General and comparative endocrinology 2019-07, Vol.278, p.79-88 |
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| container_title | General and comparative endocrinology |
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| creator | Deshpande, Sonali A. Meiselman, Matthew Hice, Robert H. Arensburger, Peter Rivera-Perez, Crisalejandra Kim, Do-Hyoung Croft, Rachel L. Noriega, Fernando Gabriel Adams, Michael E. |
| description | •ETHR silencing in antennal lobe interneurons elevates male-male courtship.•ETHR silencing in fruitless neurons increases male-male courtship.•JH deficiency does not cause elevated male-male courtship.•Genes for axon guidanceand chemosensory functions are differentially expressed.•ETHR signaling regulates Drosophila courtship via antennal lobe chemosensory processing.
Ecdysis triggering hormone receptors (ETHR) regulate the behavioral sequence necessary for cuticle shedding. Recent reports have documented functions for ETHR signaling in adult Drosophila melanogaster. In this study, we report that ETHR silencing in local interneurons of the antennal lobes and fruitless neurons leads to sharply increased rates of male-male courtship. RNAseq analysis of ETHR knockdown flies reveals differential expression of genes involved in axon guidance, courtship behavior and chemosensory functions. Our findings indicate an important role for ETHR in regulation of Drosophila courtship behavior through chemosensory processing in the antennal lobe. |
| doi_str_mv | 10.1016/j.ygcen.2018.12.003 |
| format | Article |
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Ecdysis triggering hormone receptors (ETHR) regulate the behavioral sequence necessary for cuticle shedding. Recent reports have documented functions for ETHR signaling in adult Drosophila melanogaster. In this study, we report that ETHR silencing in local interneurons of the antennal lobes and fruitless neurons leads to sharply increased rates of male-male courtship. RNAseq analysis of ETHR knockdown flies reveals differential expression of genes involved in axon guidance, courtship behavior and chemosensory functions. Our findings indicate an important role for ETHR in regulation of Drosophila courtship behavior through chemosensory processing in the antennal lobe.</description><identifier>ISSN: 0016-6480</identifier><identifier>EISSN: 1095-6840</identifier><identifier>DOI: 10.1016/j.ygcen.2018.12.003</identifier><identifier>PMID: 30543770</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Antennal lobe interneurons ; Aug21-Gal4 ; Chemosensation ; Male-male courtship ; Olfactory processing</subject><ispartof>General and comparative endocrinology, 2019-07, Vol.278, p.79-88</ispartof><rights>2018</rights><rights>Copyright © 2018. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-81395a2f325c79f925849fea0db3c3c4fcf55635ebbf49c342e6c7fadeb4db993</citedby><cites>FETCH-LOGICAL-c359t-81395a2f325c79f925849fea0db3c3c4fcf55635ebbf49c342e6c7fadeb4db993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S001664801830323X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30543770$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deshpande, Sonali A.</creatorcontrib><creatorcontrib>Meiselman, Matthew</creatorcontrib><creatorcontrib>Hice, Robert H.</creatorcontrib><creatorcontrib>Arensburger, Peter</creatorcontrib><creatorcontrib>Rivera-Perez, Crisalejandra</creatorcontrib><creatorcontrib>Kim, Do-Hyoung</creatorcontrib><creatorcontrib>Croft, Rachel L.</creatorcontrib><creatorcontrib>Noriega, Fernando Gabriel</creatorcontrib><creatorcontrib>Adams, Michael E.</creatorcontrib><title>Ecdysis triggering hormone receptors regulate male courtship behavior via antennal lobe interneurons in Drosophila</title><title>General and comparative endocrinology</title><addtitle>Gen Comp Endocrinol</addtitle><description>•ETHR silencing in antennal lobe interneurons elevates male-male courtship.•ETHR silencing in fruitless neurons increases male-male courtship.•JH deficiency does not cause elevated male-male courtship.•Genes for axon guidanceand chemosensory functions are differentially expressed.•ETHR signaling regulates Drosophila courtship via antennal lobe chemosensory processing.
Ecdysis triggering hormone receptors (ETHR) regulate the behavioral sequence necessary for cuticle shedding. Recent reports have documented functions for ETHR signaling in adult Drosophila melanogaster. In this study, we report that ETHR silencing in local interneurons of the antennal lobes and fruitless neurons leads to sharply increased rates of male-male courtship. RNAseq analysis of ETHR knockdown flies reveals differential expression of genes involved in axon guidance, courtship behavior and chemosensory functions. Our findings indicate an important role for ETHR in regulation of Drosophila courtship behavior through chemosensory processing in the antennal lobe.</description><subject>Antennal lobe interneurons</subject><subject>Aug21-Gal4</subject><subject>Chemosensation</subject><subject>Male-male courtship</subject><subject>Olfactory processing</subject><issn>0016-6480</issn><issn>1095-6840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kDuP1DAQgC3EiVsOfgESckmTMI7jJC4o0D0A6aRroLYcZ5z1KrGDnay0__687EFJNTPSN6-PkA8MSgas-XwoT6NBX1bAupJVJQB_RXYMpCiarobXZAcZK5q6g2vyNqUDAAjesDfkmoOoedvCjsR7M5ySS3SNbhwxOj_SfYhz8EgjGlzWEFPOxm3SK9JZT0hN2OKa9m6hPe710YVIj05T7Vf0Xk90Cj1Sl6vocYvBp1zQuxhSWPZu0u_IldVTwvcv8Yb8erj_efu9eHz69uP262NhuJBr0TEuha4sr4RppZWV6GppUcPQc8NNbY0VouEC-97W0vC6wsa0Vg_Y10MvJb8hny5zlxh-b5hWNbtkcJq0x7AlVTHRnuXAGeUX1OQrU0SrluhmHU-KgTrLVgf1R7Y6y1asUll27vr4smDrZxz-9fy1m4EvFwDzm0eHUSXj0BscXHa7qiG4_y54BobwlMo</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Deshpande, Sonali A.</creator><creator>Meiselman, Matthew</creator><creator>Hice, Robert H.</creator><creator>Arensburger, Peter</creator><creator>Rivera-Perez, Crisalejandra</creator><creator>Kim, Do-Hyoung</creator><creator>Croft, Rachel L.</creator><creator>Noriega, Fernando Gabriel</creator><creator>Adams, Michael E.</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190701</creationdate><title>Ecdysis triggering hormone receptors regulate male courtship behavior via antennal lobe interneurons in Drosophila</title><author>Deshpande, Sonali A. ; Meiselman, Matthew ; Hice, Robert H. ; Arensburger, Peter ; Rivera-Perez, Crisalejandra ; Kim, Do-Hyoung ; Croft, Rachel L. ; Noriega, Fernando Gabriel ; Adams, Michael E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-81395a2f325c79f925849fea0db3c3c4fcf55635ebbf49c342e6c7fadeb4db993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Antennal lobe interneurons</topic><topic>Aug21-Gal4</topic><topic>Chemosensation</topic><topic>Male-male courtship</topic><topic>Olfactory processing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Deshpande, Sonali A.</creatorcontrib><creatorcontrib>Meiselman, Matthew</creatorcontrib><creatorcontrib>Hice, Robert H.</creatorcontrib><creatorcontrib>Arensburger, Peter</creatorcontrib><creatorcontrib>Rivera-Perez, Crisalejandra</creatorcontrib><creatorcontrib>Kim, Do-Hyoung</creatorcontrib><creatorcontrib>Croft, Rachel L.</creatorcontrib><creatorcontrib>Noriega, Fernando Gabriel</creatorcontrib><creatorcontrib>Adams, Michael E.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>General and comparative endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deshpande, Sonali A.</au><au>Meiselman, Matthew</au><au>Hice, Robert H.</au><au>Arensburger, Peter</au><au>Rivera-Perez, Crisalejandra</au><au>Kim, Do-Hyoung</au><au>Croft, Rachel L.</au><au>Noriega, Fernando Gabriel</au><au>Adams, Michael E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ecdysis triggering hormone receptors regulate male courtship behavior via antennal lobe interneurons in Drosophila</atitle><jtitle>General and comparative endocrinology</jtitle><addtitle>Gen Comp Endocrinol</addtitle><date>2019-07-01</date><risdate>2019</risdate><volume>278</volume><spage>79</spage><epage>88</epage><pages>79-88</pages><issn>0016-6480</issn><eissn>1095-6840</eissn><abstract>•ETHR silencing in antennal lobe interneurons elevates male-male courtship.•ETHR silencing in fruitless neurons increases male-male courtship.•JH deficiency does not cause elevated male-male courtship.•Genes for axon guidanceand chemosensory functions are differentially expressed.•ETHR signaling regulates Drosophila courtship via antennal lobe chemosensory processing.
Ecdysis triggering hormone receptors (ETHR) regulate the behavioral sequence necessary for cuticle shedding. Recent reports have documented functions for ETHR signaling in adult Drosophila melanogaster. In this study, we report that ETHR silencing in local interneurons of the antennal lobes and fruitless neurons leads to sharply increased rates of male-male courtship. RNAseq analysis of ETHR knockdown flies reveals differential expression of genes involved in axon guidance, courtship behavior and chemosensory functions. Our findings indicate an important role for ETHR in regulation of Drosophila courtship behavior through chemosensory processing in the antennal lobe.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30543770</pmid><doi>10.1016/j.ygcen.2018.12.003</doi><tpages>10</tpages></addata></record> |
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| subjects | Antennal lobe interneurons Aug21-Gal4 Chemosensation Male-male courtship Olfactory processing |
| title | Ecdysis triggering hormone receptors regulate male courtship behavior via antennal lobe interneurons in Drosophila |
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