Role and regulation of proapoptotic Bax in oral squamous cell carcinoma and drug resistance

Background Bax, a proapoptotic protein but its regulation during oral cancer progression and resistance remains elusive. Methods A total of 127 samples including adjacent normal, primary tumor, and resistance to chemoradiation therapy (RCRT) samples from oral squamous cell carcinoma (OSCC) patients...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Head & neck 2019-01, Vol.41 (1), p.185-197
Hauptverfasser:	Alam, Manzar, Kashyap, Tanushree, Mishra, Prajna, Panda, Aditya K., Nagini, Siddavaram, Mishra, Rajakishore
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Akt AKT protein Antineoplastic Agents - pharmacology Apoptosis Bax BAX gene bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Bcl‐2 Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - therapy Cell death Cell Line, Tumor chemoradiation resistance Chemoradiotherapy Cisplatin Cisplatin - pharmacology Deoxyribonucleic acid Disease Progression DNA DNA methylation Drug resistance Drug Resistance, Neoplasm Female GSK3α GSK3β Head and neck Humans Limonins - pharmacology Male Middle Aged Mouth Neoplasms - metabolism Mouth Neoplasms - pathology Mouth Neoplasms - therapy mRNA Oncogene Protein v-akt - metabolism Oral cancer Oral squamous cell carcinoma OSCC p53 p53 Protein Polymorphism, Single Nucleotide Promoter Regions, Genetic RNA, Messenger - metabolism Squamous cell carcinoma Tumor Suppressor Protein p53 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!