TLR4 (toll-like receptor 4) activation suppresses autophagy through inhibition of FOXO3 and impairs phagocytic capacity of microglia

Macroautophagy/autophagy is a lysosome-dependent catabolic process for the turnover of proteins and organelles in eukaryotes. Autophagy plays an important role in immunity and inflammation, as well as metabolism and cell survival. Diverse immune and inflammatory signals induce autophagy in macrophag...

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Veröffentlicht in:	Autophagy 2019-05, Vol.15 (5), p.753-770
Hauptverfasser:	Lee, Ji-Won, Nam, Hyeri, Kim, Leah Eunjung, Jeon, Yoonjeong, Min, Hyunjung, Ha, Shinwon, Lee, Younghwan, Kim, Seon-Young, Lee, Sung Joong, Kim, Eun-Kyoung, Yu, Seong-Woon
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid Amyloid beta-Peptides - pharmacology Animals Animals, Newborn Autophagy - drug effects Autophagy - genetics Cells, Cultured Down-Regulation - drug effects Down-Regulation - genetics Forkhead Box Protein O3 - genetics Forkhead Box Protein O3 - metabolism FOXO3 LC3-associated phagocytosis Lipopolysaccharides - pharmacology Macrophages - drug effects Macrophages - metabolism Mice Mice, Inbred C57BL Mice, Knockout microglia Microglia - physiology Phagocytosis - genetics Phosphatidylinositol 3-Kinases - metabolism PI3K PtdIns3K RAW 264.7 Cells Research Paper Signal Transduction - drug effects Signal Transduction - genetics Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Toll-Like Receptor 4 - physiology
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