Flow cytometry for fast screening and automated risk assessment in systemic light-chain amyloidosis

Early diagnosis and risk stratification are key to improve outcomes in light-chain (AL) amyloidosis. Here we used multidimensional-flow-cytometry (MFC) to characterize bone marrow (BM) plasma cells (PCs) from a series of 166 patients including newly-diagnosed AL amyloidosis ( N = 94), MGUS ( N = 2...

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Veröffentlicht in:	Leukemia 2019-05, Vol.33 (5), p.1256-1267
Hauptverfasser:	Puig, Noemi, Paiva, Bruno, Lasa, Marta, Burgos, Leire, Perez, Jose J., Merino, Juana, Moreno, Cristina, Vidriales, Maria-Belen, Toboso, Dolores Gómez, Cedena, Maria-Teresa, Ocio, Enrique M., Lecumberri, Ramon, García de Coca, Alfonso, Labrador, Jorge, Gonzalez, Maria-Esther, Palomera, Luis, Gironella, Mercedes, Cabañas, Valentin, Casanova, Maria, Oriol, Albert, Krsnik, Isabel, Pérez-Montaña, Albert, de la Rubia, Javier, de la Puerta, Jose-Enrique, de Arriba, Felipe, Prosper, Felipe, Martinez-Lopez, Joaquin, Lecrevisse, Quentin, Verde, Javier, Mateos, Maria-Victoria, Lahuerta, Juan-Jose, Orfao, Alberto, San Miguel, Jesús F.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1990/804 692/308/575 692/699/1541/1990 Adult Aged Aged, 80 and over Amyloidosis Analysis Automation Biological markers Biomarkers Bone marrow Bone Marrow - metabolism Cancer Research Cancer screening CD56 antigen Chains Clonal Evolution Critical Care Medicine Development and progression Diagnosis Female Flow Cytometry Genetic aspects Health risk assessment Hematology Humans Immunoglobulin Isotypes - blood Immunoglobulin Light-chain Amyloidosis - diagnosis Immunoglobulin Light-chain Amyloidosis - epidemiology Immunoglobulin Light-chain Amyloidosis - mortality Immunophenotyping Intensive Internal Medicine Lymphocytes B Male Mass Screening Medical screening Medicine Medicine & Public Health Middle Aged Multiple myeloma Neoplasm Staging Oncology Plasma cells Risk Assessment Tumors
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