Peer victimization and its impact on adolescent brain development and psychopathology
Chronic peer victimization has long-term impacts on mental health; however, the biological mediators of this adverse relationship are unknown. We sought to determine whether adolescent brain development is involved in mediating the effect of peer victimization on psychopathology. We included partici...
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| Veröffentlicht in: | Molecular psychiatry 2020-11, Vol.25 (11), p.3066-3076 |
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| creator | Quinlan, Erin Burke Barker, Edward D. Luo, Qiang Banaschewski, Tobias Bokde, Arun L. W. Bromberg, Uli Büchel, Christian Desrivières, Sylvane Flor, Herta Frouin, Vincent Garavan, Hugh Chaarani, Bader Gowland, Penny Heinz, Andreas Brühl, Rüdiger Martinot, Jean-Luc Martinot, Marie-Laure Paillère Nees, Frauke Orfanos, Dimitri Papadopoulos Paus, Tomáš Poustka, Luise Hohmann, Sarah Smolka, Michael N. Fröhner, Juliane H. Walter, Henrik Whelan, Robert Schumann, Gunter |
| description | Chronic peer victimization has long-term impacts on mental health; however, the biological mediators of this adverse relationship are unknown. We sought to determine whether adolescent brain development is involved in mediating the effect of peer victimization on psychopathology. We included participants (
n
= 682) from the longitudinal IMAGEN study with both peer victimization and neuroimaging data. Latent profile analysis identified groups of adolescents with different experiential patterns of victimization. We then associated the victimization trajectories and brain volume changes with depression, generalized anxiety, and hyperactivity symptoms at age 19. Repeated measures ANOVA revealed time-by-victimization interactions on left putamen volume (
F
= 4.38,
p
= 0.037). Changes in left putamen volume were negatively associated with generalized anxiety (
t
= −2.32,
p
= 0.020). Notably, peer victimization was indirectly associated with generalized anxiety via decreases in putamen volume (95% CI = 0.004–0.109). This was also true for the left caudate (95% CI = 0.002–0.099). These data suggest that the experience of chronic peer victimization during adolescence might induce psychopathology-relevant deviations from normative brain development. Early peer victimization interventions could prevent such pathological changes. |
| doi_str_mv | 10.1038/s41380-018-0297-9 |
| format | Article |
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n
= 682) from the longitudinal IMAGEN study with both peer victimization and neuroimaging data. Latent profile analysis identified groups of adolescents with different experiential patterns of victimization. We then associated the victimization trajectories and brain volume changes with depression, generalized anxiety, and hyperactivity symptoms at age 19. Repeated measures ANOVA revealed time-by-victimization interactions on left putamen volume (
F
= 4.38,
p
= 0.037). Changes in left putamen volume were negatively associated with generalized anxiety (
t
= −2.32,
p
= 0.020). Notably, peer victimization was indirectly associated with generalized anxiety via decreases in putamen volume (95% CI = 0.004–0.109). This was also true for the left caudate (95% CI = 0.002–0.099). These data suggest that the experience of chronic peer victimization during adolescence might induce psychopathology-relevant deviations from normative brain development. Early peer victimization interventions could prevent such pathological changes.</description><identifier>ISSN: 1359-4184</identifier><identifier>EISSN: 1476-5578</identifier><identifier>DOI: 10.1038/s41380-018-0297-9</identifier><identifier>PMID: 30542059</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>59 ; 59/57 ; 692/699 ; 692/699/476 ; Adolescent ; Anxiety ; Behavioral Sciences ; Biological Psychology ; Brain ; Brain - growth & development ; Brain - pathology ; Bullying - psychology ; Child development ; Crime Victims - psychology ; Depression - pathology ; Female ; Humans ; Hyperactivity ; Longitudinal Studies ; Male ; Medicine ; Medicine & Public Health ; Mental health ; Neuroimaging ; Neurosciences ; Peer Group ; Pharmacotherapy ; Psychiatry ; Psychological aspects ; Psychology, Pathological ; Psychopathology ; Putamen ; Teenagers ; Victimization ; Youth</subject><ispartof>Molecular psychiatry, 2020-11, Vol.25 (11), p.3066-3076</ispartof><rights>Springer Nature Limited 2018</rights><rights>COPYRIGHT 2020 Nature Publishing Group</rights><rights>Springer Nature Limited 2018.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c548t-1d13a2338630ff35ca96caf0f2b9bb46db76176fb5e068262bb363e6842e01683</citedby><cites>FETCH-LOGICAL-c548t-1d13a2338630ff35ca96caf0f2b9bb46db76176fb5e068262bb363e6842e01683</cites><orcidid>0000-0002-9403-6121 ; 0000-0001-5398-5569 ; 0000-0003-4974-971X ; 0000-0002-9120-7060 ; 0000-0001-9360-6623 ; 0000-0002-1242-8990 ; 0000-0003-1965-906X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41380-018-0297-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41380-018-0297-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30542059$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Quinlan, Erin Burke</creatorcontrib><creatorcontrib>Barker, Edward D.</creatorcontrib><creatorcontrib>Luo, Qiang</creatorcontrib><creatorcontrib>Banaschewski, Tobias</creatorcontrib><creatorcontrib>Bokde, Arun L. W.</creatorcontrib><creatorcontrib>Bromberg, Uli</creatorcontrib><creatorcontrib>Büchel, Christian</creatorcontrib><creatorcontrib>Desrivières, Sylvane</creatorcontrib><creatorcontrib>Flor, Herta</creatorcontrib><creatorcontrib>Frouin, Vincent</creatorcontrib><creatorcontrib>Garavan, Hugh</creatorcontrib><creatorcontrib>Chaarani, Bader</creatorcontrib><creatorcontrib>Gowland, Penny</creatorcontrib><creatorcontrib>Heinz, Andreas</creatorcontrib><creatorcontrib>Brühl, Rüdiger</creatorcontrib><creatorcontrib>Martinot, Jean-Luc</creatorcontrib><creatorcontrib>Martinot, Marie-Laure Paillère</creatorcontrib><creatorcontrib>Nees, Frauke</creatorcontrib><creatorcontrib>Orfanos, Dimitri Papadopoulos</creatorcontrib><creatorcontrib>Paus, Tomáš</creatorcontrib><creatorcontrib>Poustka, Luise</creatorcontrib><creatorcontrib>Hohmann, Sarah</creatorcontrib><creatorcontrib>Smolka, Michael N.</creatorcontrib><creatorcontrib>Fröhner, Juliane H.</creatorcontrib><creatorcontrib>Walter, Henrik</creatorcontrib><creatorcontrib>Whelan, Robert</creatorcontrib><creatorcontrib>Schumann, Gunter</creatorcontrib><creatorcontrib>IMAGEN Consortium</creatorcontrib><title>Peer victimization and its impact on adolescent brain development and psychopathology</title><title>Molecular psychiatry</title><addtitle>Mol Psychiatry</addtitle><addtitle>Mol Psychiatry</addtitle><description>Chronic peer victimization has long-term impacts on mental health; however, the biological mediators of this adverse relationship are unknown. We sought to determine whether adolescent brain development is involved in mediating the effect of peer victimization on psychopathology. We included participants (
n
= 682) from the longitudinal IMAGEN study with both peer victimization and neuroimaging data. Latent profile analysis identified groups of adolescents with different experiential patterns of victimization. We then associated the victimization trajectories and brain volume changes with depression, generalized anxiety, and hyperactivity symptoms at age 19. Repeated measures ANOVA revealed time-by-victimization interactions on left putamen volume (
F
= 4.38,
p
= 0.037). Changes in left putamen volume were negatively associated with generalized anxiety (
t
= −2.32,
p
= 0.020). Notably, peer victimization was indirectly associated with generalized anxiety via decreases in putamen volume (95% CI = 0.004–0.109). This was also true for the left caudate (95% CI = 0.002–0.099). These data suggest that the experience of chronic peer victimization during adolescence might induce psychopathology-relevant deviations from normative brain development. Early peer victimization interventions could prevent such pathological changes.</description><subject>59</subject><subject>59/57</subject><subject>692/699</subject><subject>692/699/476</subject><subject>Adolescent</subject><subject>Anxiety</subject><subject>Behavioral Sciences</subject><subject>Biological Psychology</subject><subject>Brain</subject><subject>Brain - growth & development</subject><subject>Brain - pathology</subject><subject>Bullying - psychology</subject><subject>Child development</subject><subject>Crime Victims - psychology</subject><subject>Depression - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperactivity</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental health</subject><subject>Neuroimaging</subject><subject>Neurosciences</subject><subject>Peer Group</subject><subject>Pharmacotherapy</subject><subject>Psychiatry</subject><subject>Psychological aspects</subject><subject>Psychology, Pathological</subject><subject>Psychopathology</subject><subject>Putamen</subject><subject>Teenagers</subject><subject>Victimization</subject><subject>Youth</subject><issn>1359-4184</issn><issn>1476-5578</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU1rFTEYhQdRbK3-ADcy4MbN1HxPsizFLyjowq5DknlzmzKTjElu4fbXm-FWi6JkkXDe57yccLruNUbnGFH5vjBMJRoQlgMiahzUk-4Us1EMnI_yaXtTrgaGJTvpXpRyi9A25M-7E4o4I4ir0-76G0Du74KrYQn3poYUexOnPtTSh2U1rvabMqUZioNYe5tNiP0EdzCnddmUDV_Lwd2k1dSbNKfd4WX3zJu5wKuH-6y7_vjh--Xn4errpy-XF1eD40zWAU-YGkKpFBR5T7kzSjjjkSdWWcvEZEeBR-EtByQkEcRaKigIyQggLCQ9694d9645_dhDqXoJLeY8mwhpXzTBnCuMBBENffsXepv2ObZ0mrARM6UkZo_UzsygQ_SpZuO2pfpCUIXxqAhq1Pk_qHYmWIJLEXxo-h8GfDS4nErJ4PWaw2LyQWOktyr1sUrdqtRblVo1z5uHwHu7wPTb8au7BpAjUNoo7iA__uj_W38Cx12nRQ</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Quinlan, Erin Burke</creator><creator>Barker, Edward D.</creator><creator>Luo, Qiang</creator><creator>Banaschewski, Tobias</creator><creator>Bokde, Arun L. 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W. ; Bromberg, Uli ; Büchel, Christian ; Desrivières, Sylvane ; Flor, Herta ; Frouin, Vincent ; Garavan, Hugh ; Chaarani, Bader ; Gowland, Penny ; Heinz, Andreas ; Brühl, Rüdiger ; Martinot, Jean-Luc ; Martinot, Marie-Laure Paillère ; Nees, Frauke ; Orfanos, Dimitri Papadopoulos ; Paus, Tomáš ; Poustka, Luise ; Hohmann, Sarah ; Smolka, Michael N. ; Fröhner, Juliane H. ; Walter, Henrik ; Whelan, Robert ; Schumann, Gunter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c548t-1d13a2338630ff35ca96caf0f2b9bb46db76176fb5e068262bb363e6842e01683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>59</topic><topic>59/57</topic><topic>692/699</topic><topic>692/699/476</topic><topic>Adolescent</topic><topic>Anxiety</topic><topic>Behavioral Sciences</topic><topic>Biological Psychology</topic><topic>Brain</topic><topic>Brain - growth & development</topic><topic>Brain - pathology</topic><topic>Bullying - psychology</topic><topic>Child development</topic><topic>Crime Victims - psychology</topic><topic>Depression - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperactivity</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mental health</topic><topic>Neuroimaging</topic><topic>Neurosciences</topic><topic>Peer Group</topic><topic>Pharmacotherapy</topic><topic>Psychiatry</topic><topic>Psychological aspects</topic><topic>Psychology, Pathological</topic><topic>Psychopathology</topic><topic>Putamen</topic><topic>Teenagers</topic><topic>Victimization</topic><topic>Youth</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Quinlan, Erin Burke</creatorcontrib><creatorcontrib>Barker, Edward D.</creatorcontrib><creatorcontrib>Luo, Qiang</creatorcontrib><creatorcontrib>Banaschewski, Tobias</creatorcontrib><creatorcontrib>Bokde, Arun L. 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W.</au><au>Bromberg, Uli</au><au>Büchel, Christian</au><au>Desrivières, Sylvane</au><au>Flor, Herta</au><au>Frouin, Vincent</au><au>Garavan, Hugh</au><au>Chaarani, Bader</au><au>Gowland, Penny</au><au>Heinz, Andreas</au><au>Brühl, Rüdiger</au><au>Martinot, Jean-Luc</au><au>Martinot, Marie-Laure Paillère</au><au>Nees, Frauke</au><au>Orfanos, Dimitri Papadopoulos</au><au>Paus, Tomáš</au><au>Poustka, Luise</au><au>Hohmann, Sarah</au><au>Smolka, Michael N.</au><au>Fröhner, Juliane H.</au><au>Walter, Henrik</au><au>Whelan, Robert</au><au>Schumann, Gunter</au><aucorp>IMAGEN Consortium</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peer victimization and its impact on adolescent brain development and psychopathology</atitle><jtitle>Molecular psychiatry</jtitle><stitle>Mol Psychiatry</stitle><addtitle>Mol Psychiatry</addtitle><date>2020-11-01</date><risdate>2020</risdate><volume>25</volume><issue>11</issue><spage>3066</spage><epage>3076</epage><pages>3066-3076</pages><issn>1359-4184</issn><eissn>1476-5578</eissn><abstract>Chronic peer victimization has long-term impacts on mental health; however, the biological mediators of this adverse relationship are unknown. We sought to determine whether adolescent brain development is involved in mediating the effect of peer victimization on psychopathology. We included participants (
n
= 682) from the longitudinal IMAGEN study with both peer victimization and neuroimaging data. Latent profile analysis identified groups of adolescents with different experiential patterns of victimization. We then associated the victimization trajectories and brain volume changes with depression, generalized anxiety, and hyperactivity symptoms at age 19. Repeated measures ANOVA revealed time-by-victimization interactions on left putamen volume (
F
= 4.38,
p
= 0.037). Changes in left putamen volume were negatively associated with generalized anxiety (
t
= −2.32,
p
= 0.020). Notably, peer victimization was indirectly associated with generalized anxiety via decreases in putamen volume (95% CI = 0.004–0.109). This was also true for the left caudate (95% CI = 0.002–0.099). These data suggest that the experience of chronic peer victimization during adolescence might induce psychopathology-relevant deviations from normative brain development. Early peer victimization interventions could prevent such pathological changes.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30542059</pmid><doi>10.1038/s41380-018-0297-9</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-9403-6121</orcidid><orcidid>https://orcid.org/0000-0001-5398-5569</orcidid><orcidid>https://orcid.org/0000-0003-4974-971X</orcidid><orcidid>https://orcid.org/0000-0002-9120-7060</orcidid><orcidid>https://orcid.org/0000-0001-9360-6623</orcidid><orcidid>https://orcid.org/0000-0002-1242-8990</orcidid><orcidid>https://orcid.org/0000-0003-1965-906X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1359-4184 |
| ispartof | Molecular psychiatry, 2020-11, Vol.25 (11), p.3066-3076 |
| issn | 1359-4184 1476-5578 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2155910626 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | 59 59/57 692/699 692/699/476 Adolescent Anxiety Behavioral Sciences Biological Psychology Brain Brain - growth & development Brain - pathology Bullying - psychology Child development Crime Victims - psychology Depression - pathology Female Humans Hyperactivity Longitudinal Studies Male Medicine Medicine & Public Health Mental health Neuroimaging Neurosciences Peer Group Pharmacotherapy Psychiatry Psychological aspects Psychology, Pathological Psychopathology Putamen Teenagers Victimization Youth |
| title | Peer victimization and its impact on adolescent brain development and psychopathology |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T14%3A28%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Peer%20victimization%20and%20its%20impact%20on%20adolescent%20brain%20development%20and%20psychopathology&rft.jtitle=Molecular%20psychiatry&rft.au=Quinlan,%20Erin%20Burke&rft.aucorp=IMAGEN%20Consortium&rft.date=2020-11-01&rft.volume=25&rft.issue=11&rft.spage=3066&rft.epage=3076&rft.pages=3066-3076&rft.issn=1359-4184&rft.eissn=1476-5578&rft_id=info:doi/10.1038/s41380-018-0297-9&rft_dat=%3Cgale_proqu%3EA639117920%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2471499814&rft_id=info:pmid/30542059&rft_galeid=A639117920&rfr_iscdi=true |