Management of endometrial, ovarian and cervical cancer in the elderly: current approach to a challenging condition
Purpose Gynaecological cancer management in older people represents a current challenge. Therefore, in the present paper, we aimed to gather all the evidence reported in the literature concerning gynecological cancers in the elderly, illustrating the state of art and the future perspectives. Methods...
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| Veröffentlicht in: | Archives of gynecology and obstetrics 2019-02, Vol.299 (2), p.299-315 |
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| creator | Vitale, Salvatore Giovanni Capriglione, Stella Zito, Gabriella Lopez, Salvatore Gulino, Ferdinando Antonio Di Guardo, Federica Vitagliano, Amerigo Noventa, Marco La Rosa, Valentina Lucia Sapia, Fabrizio Valenti, Gaetano Rapisarda, Agnese Maria Chiara Peterlunger, Isabel Rossetti, Diego Laganà, Antonio Simone |
| description | Purpose
Gynaecological cancer management in older people represents a current challenge. Therefore, in the present paper, we aimed to gather all the evidence reported in the literature concerning gynecological cancers in the elderly, illustrating the state of art and the future perspectives.
Methods
We searched MEDLINE (PubMed), EMBASE, Cochrane Central Register of Controlled Trials, IBECS, BIOSIS, Web of Science, SCOPUS and Grey literature (Google Scholar; British Library) from January 1952 to May 2017, using the terms “ovarian cancer”, “endometrial cancer”, “cervical cancer”, “gynecological cancers” combined with ‘elderly’, ‘cancer’, ‘clinical trial’ and ‘geriatric assessment’.
Results
The search identified 81 citations, of which 65 were potentially relevant after initial evaluation and met the criteria for inclusion and were analyzed. We divided all included studies into three different issue: “Endometrial cancer”, “Ovarian cancer” and “Cervical cancer”.
Conclusions
The present literature review shows that, in spite of the higher burden of comorbidities, elderly patients can also benefit from standard treatment to manage their gynecological cancers. It is important to overcome the common habit of undertreating the elderly patients because they are more fragile and with a lower life expectancy than their younger counterpart. Further trials with elderly women are warranted. |
| doi_str_mv | 10.1007/s00404-018-5006-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2155907166</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2155907166</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-1468b21bcd03d9b5cd5a9b673397e811637fdb95ead60702bdff113fc58463753</originalsourceid><addsrcrecordid>eNp1kUFr3DAQhUVoaLab_oBeiqCXHup0JFmy3VsJbRNIyKU5C1ka7zrI0layA8mvj5ZNWijkNA_mmzfDPEI-MDhjAM3XDFBDXQFrKwmgqscjsmK14BU0jL0hK-j2GlRzQt7lfAfAeNuqt-REgKx504kVSdcmmA1OGGYaB4rBxQnnNBr_hcZ7U0SgJjhqMd2P1nhqTSiajoHOW6ToHSb_8I3aJaW9h9ntUjR2S-dIDbVb4z2GzRg21MbgxnmM4ZQcD8ZnfP9c1-T254_f5xfV1c2vy_PvV5WtRTtXrFZtz1lvHQjX9dI6abpeNUJ0DbaMKdEMru8kGqegAd67YWBMDFa2delJsSafD77loj8L5llPY7bovQkYl6w5k7Irn1KqoJ_-Q-_ikkK5TnMuWyZrURavCTtQNsWcEw56l8bJpAfNQO8D0YdAdAlE7wPRj2Xm47Pz0k_o_k68JFAAfgByaYUNpn-rX3d9AlRolps</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2258154367</pqid></control><display><type>article</type><title>Management of endometrial, ovarian and cervical cancer in the elderly: current approach to a challenging condition</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Vitale, Salvatore Giovanni ; Capriglione, Stella ; Zito, Gabriella ; Lopez, Salvatore ; Gulino, Ferdinando Antonio ; Di Guardo, Federica ; Vitagliano, Amerigo ; Noventa, Marco ; La Rosa, Valentina Lucia ; Sapia, Fabrizio ; Valenti, Gaetano ; Rapisarda, Agnese Maria Chiara ; Peterlunger, Isabel ; Rossetti, Diego ; Laganà, Antonio Simone</creator><creatorcontrib>Vitale, Salvatore Giovanni ; Capriglione, Stella ; Zito, Gabriella ; Lopez, Salvatore ; Gulino, Ferdinando Antonio ; Di Guardo, Federica ; Vitagliano, Amerigo ; Noventa, Marco ; La Rosa, Valentina Lucia ; Sapia, Fabrizio ; Valenti, Gaetano ; Rapisarda, Agnese Maria Chiara ; Peterlunger, Isabel ; Rossetti, Diego ; Laganà, Antonio Simone</creatorcontrib><description>Purpose
Gynaecological cancer management in older people represents a current challenge. Therefore, in the present paper, we aimed to gather all the evidence reported in the literature concerning gynecological cancers in the elderly, illustrating the state of art and the future perspectives.
Methods
We searched MEDLINE (PubMed), EMBASE, Cochrane Central Register of Controlled Trials, IBECS, BIOSIS, Web of Science, SCOPUS and Grey literature (Google Scholar; British Library) from January 1952 to May 2017, using the terms “ovarian cancer”, “endometrial cancer”, “cervical cancer”, “gynecological cancers” combined with ‘elderly’, ‘cancer’, ‘clinical trial’ and ‘geriatric assessment’.
Results
The search identified 81 citations, of which 65 were potentially relevant after initial evaluation and met the criteria for inclusion and were analyzed. We divided all included studies into three different issue: “Endometrial cancer”, “Ovarian cancer” and “Cervical cancer”.
Conclusions
The present literature review shows that, in spite of the higher burden of comorbidities, elderly patients can also benefit from standard treatment to manage their gynecological cancers. It is important to overcome the common habit of undertreating the elderly patients because they are more fragile and with a lower life expectancy than their younger counterpart. Further trials with elderly women are warranted.</description><identifier>ISSN: 0932-0067</identifier><identifier>EISSN: 1432-0711</identifier><identifier>DOI: 10.1007/s00404-018-5006-z</identifier><identifier>PMID: 30542793</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Aged, 80 and over ; Cervical cancer ; Endocrinology ; Endometrial cancer ; Endometrial Neoplasms - therapy ; Female ; Genital Neoplasms, Female - therapy ; Gynecological cancer ; Gynecology ; Human Genetics ; Humans ; Medicine ; Medicine & Public Health ; Obstetrics/Perinatology/Midwifery ; Older people ; Ovarian cancer ; Ovarian Neoplasms - therapy ; Review ; Uterine Cervical Neoplasms - therapy</subject><ispartof>Archives of gynecology and obstetrics, 2019-02, Vol.299 (2), p.299-315</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>Archives of Gynecology and Obstetrics is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-1468b21bcd03d9b5cd5a9b673397e811637fdb95ead60702bdff113fc58463753</citedby><cites>FETCH-LOGICAL-c438t-1468b21bcd03d9b5cd5a9b673397e811637fdb95ead60702bdff113fc58463753</cites><orcidid>0000-0001-6962-520X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00404-018-5006-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00404-018-5006-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30542793$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vitale, Salvatore Giovanni</creatorcontrib><creatorcontrib>Capriglione, Stella</creatorcontrib><creatorcontrib>Zito, Gabriella</creatorcontrib><creatorcontrib>Lopez, Salvatore</creatorcontrib><creatorcontrib>Gulino, Ferdinando Antonio</creatorcontrib><creatorcontrib>Di Guardo, Federica</creatorcontrib><creatorcontrib>Vitagliano, Amerigo</creatorcontrib><creatorcontrib>Noventa, Marco</creatorcontrib><creatorcontrib>La Rosa, Valentina Lucia</creatorcontrib><creatorcontrib>Sapia, Fabrizio</creatorcontrib><creatorcontrib>Valenti, Gaetano</creatorcontrib><creatorcontrib>Rapisarda, Agnese Maria Chiara</creatorcontrib><creatorcontrib>Peterlunger, Isabel</creatorcontrib><creatorcontrib>Rossetti, Diego</creatorcontrib><creatorcontrib>Laganà, Antonio Simone</creatorcontrib><title>Management of endometrial, ovarian and cervical cancer in the elderly: current approach to a challenging condition</title><title>Archives of gynecology and obstetrics</title><addtitle>Arch Gynecol Obstet</addtitle><addtitle>Arch Gynecol Obstet</addtitle><description>Purpose
Gynaecological cancer management in older people represents a current challenge. Therefore, in the present paper, we aimed to gather all the evidence reported in the literature concerning gynecological cancers in the elderly, illustrating the state of art and the future perspectives.
Methods
We searched MEDLINE (PubMed), EMBASE, Cochrane Central Register of Controlled Trials, IBECS, BIOSIS, Web of Science, SCOPUS and Grey literature (Google Scholar; British Library) from January 1952 to May 2017, using the terms “ovarian cancer”, “endometrial cancer”, “cervical cancer”, “gynecological cancers” combined with ‘elderly’, ‘cancer’, ‘clinical trial’ and ‘geriatric assessment’.
Results
The search identified 81 citations, of which 65 were potentially relevant after initial evaluation and met the criteria for inclusion and were analyzed. We divided all included studies into three different issue: “Endometrial cancer”, “Ovarian cancer” and “Cervical cancer”.
Conclusions
The present literature review shows that, in spite of the higher burden of comorbidities, elderly patients can also benefit from standard treatment to manage their gynecological cancers. It is important to overcome the common habit of undertreating the elderly patients because they are more fragile and with a lower life expectancy than their younger counterpart. Further trials with elderly women are warranted.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cervical cancer</subject><subject>Endocrinology</subject><subject>Endometrial cancer</subject><subject>Endometrial Neoplasms - therapy</subject><subject>Female</subject><subject>Genital Neoplasms, Female - therapy</subject><subject>Gynecological cancer</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Older people</subject><subject>Ovarian cancer</subject><subject>Ovarian Neoplasms - therapy</subject><subject>Review</subject><subject>Uterine Cervical Neoplasms - therapy</subject><issn>0932-0067</issn><issn>1432-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kUFr3DAQhUVoaLab_oBeiqCXHup0JFmy3VsJbRNIyKU5C1ka7zrI0layA8mvj5ZNWijkNA_mmzfDPEI-MDhjAM3XDFBDXQFrKwmgqscjsmK14BU0jL0hK-j2GlRzQt7lfAfAeNuqt-REgKx504kVSdcmmA1OGGYaB4rBxQnnNBr_hcZ7U0SgJjhqMd2P1nhqTSiajoHOW6ToHSb_8I3aJaW9h9ntUjR2S-dIDbVb4z2GzRg21MbgxnmM4ZQcD8ZnfP9c1-T254_f5xfV1c2vy_PvV5WtRTtXrFZtz1lvHQjX9dI6abpeNUJ0DbaMKdEMru8kGqegAd67YWBMDFa2delJsSafD77loj8L5llPY7bovQkYl6w5k7Irn1KqoJ_-Q-_ikkK5TnMuWyZrURavCTtQNsWcEw56l8bJpAfNQO8D0YdAdAlE7wPRj2Xm47Pz0k_o_k68JFAAfgByaYUNpn-rX3d9AlRolps</recordid><startdate>20190201</startdate><enddate>20190201</enddate><creator>Vitale, Salvatore Giovanni</creator><creator>Capriglione, Stella</creator><creator>Zito, Gabriella</creator><creator>Lopez, Salvatore</creator><creator>Gulino, Ferdinando Antonio</creator><creator>Di Guardo, Federica</creator><creator>Vitagliano, Amerigo</creator><creator>Noventa, Marco</creator><creator>La Rosa, Valentina Lucia</creator><creator>Sapia, Fabrizio</creator><creator>Valenti, Gaetano</creator><creator>Rapisarda, Agnese Maria Chiara</creator><creator>Peterlunger, Isabel</creator><creator>Rossetti, Diego</creator><creator>Laganà, Antonio Simone</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6962-520X</orcidid></search><sort><creationdate>20190201</creationdate><title>Management of endometrial, ovarian and cervical cancer in the elderly: current approach to a challenging condition</title><author>Vitale, Salvatore Giovanni ; 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Gynaecological cancer management in older people represents a current challenge. Therefore, in the present paper, we aimed to gather all the evidence reported in the literature concerning gynecological cancers in the elderly, illustrating the state of art and the future perspectives.
Methods
We searched MEDLINE (PubMed), EMBASE, Cochrane Central Register of Controlled Trials, IBECS, BIOSIS, Web of Science, SCOPUS and Grey literature (Google Scholar; British Library) from January 1952 to May 2017, using the terms “ovarian cancer”, “endometrial cancer”, “cervical cancer”, “gynecological cancers” combined with ‘elderly’, ‘cancer’, ‘clinical trial’ and ‘geriatric assessment’.
Results
The search identified 81 citations, of which 65 were potentially relevant after initial evaluation and met the criteria for inclusion and were analyzed. We divided all included studies into three different issue: “Endometrial cancer”, “Ovarian cancer” and “Cervical cancer”.
Conclusions
The present literature review shows that, in spite of the higher burden of comorbidities, elderly patients can also benefit from standard treatment to manage their gynecological cancers. It is important to overcome the common habit of undertreating the elderly patients because they are more fragile and with a lower life expectancy than their younger counterpart. Further trials with elderly women are warranted.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30542793</pmid><doi>10.1007/s00404-018-5006-z</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0001-6962-520X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0932-0067 |
| ispartof | Archives of gynecology and obstetrics, 2019-02, Vol.299 (2), p.299-315 |
| issn | 0932-0067 1432-0711 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Aged Aged, 80 and over Cervical cancer Endocrinology Endometrial cancer Endometrial Neoplasms - therapy Female Genital Neoplasms, Female - therapy Gynecological cancer Gynecology Human Genetics Humans Medicine Medicine & Public Health Obstetrics/Perinatology/Midwifery Older people Ovarian cancer Ovarian Neoplasms - therapy Review Uterine Cervical Neoplasms - therapy |
| title | Management of endometrial, ovarian and cervical cancer in the elderly: current approach to a challenging condition |
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