On-demand release of ciprofloxacin from a smart nanofiber depot with acoustic stimulus
Herein, an antibiotic-loaded electrospun scaffold with improved drug delivery via acoustic stimulation has been developed. Ultrasound stimulus with an intensity of 15 W/cm 2 , duty-cycle of 50% and duration of 10 min was repeatedly applied to ciprofloxacin loaded alginate fibers. Ultrasonication wit...
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| Veröffentlicht in: | Journal of biosciences 2018-12, Vol.43 (5), p.959-967 |
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| container_title | Journal of biosciences |
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| creator | Khorshidi, Sajedeh Karkhaneh, Akbar |
| description | Herein, an antibiotic-loaded electrospun scaffold with improved drug delivery via acoustic stimulation has been developed. Ultrasound stimulus with an intensity of 15 W/cm
2
, duty-cycle of 50% and duration of 10 min was repeatedly applied to ciprofloxacin loaded alginate fibers. Ultrasonication with the aforesaid conditions increased drug release from scaffold probably due to disturbance of ionic crosslinks of alginate network. Scaffolds exposed to acoustic stimulus revealed higher antibacterial activity compared to those with no stimulus. Interestingly, antibiotic release radically increased and antibacterial function improved as ultrasound perturbed scaffold framework, but scaffold integrity was regained once the ultrasound probe was retracted. |
| doi_str_mv | 10.1007/s12038-018-9808-8 |
| format | Article |
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2
, duty-cycle of 50% and duration of 10 min was repeatedly applied to ciprofloxacin loaded alginate fibers. Ultrasonication with the aforesaid conditions increased drug release from scaffold probably due to disturbance of ionic crosslinks of alginate network. Scaffolds exposed to acoustic stimulus revealed higher antibacterial activity compared to those with no stimulus. Interestingly, antibiotic release radically increased and antibacterial function improved as ultrasound perturbed scaffold framework, but scaffold integrity was regained once the ultrasound probe was retracted.</description><identifier>ISSN: 0250-5991</identifier><identifier>EISSN: 0973-7138</identifier><identifier>DOI: 10.1007/s12038-018-9808-8</identifier><identifier>PMID: 30541956</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Acoustics ; Alginates ; Alginic acid ; Antibacterial activity ; Antibiotics ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Ciprofloxacin ; Crosslinking ; Drug delivery ; Drug delivery systems ; Drugs ; Duration ; Fibers ; Frameworks ; Life Sciences ; Microbiology ; Nanofibers ; Plant Sciences ; Scaffolds ; Seaweed meal ; Ultrasonic imaging ; Ultrasound ; Zoology</subject><ispartof>Journal of biosciences, 2018-12, Vol.43 (5), p.959-967</ispartof><rights>Indian Academy of Sciences 2018</rights><rights>Journal of Biosciences is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-d1185c3fad6c4e30addd18f0c9bce6dec5e4b36560825b55c919b176c0de6ff43</citedby><cites>FETCH-LOGICAL-c372t-d1185c3fad6c4e30addd18f0c9bce6dec5e4b36560825b55c919b176c0de6ff43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12038-018-9808-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12038-018-9808-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30541956$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khorshidi, Sajedeh</creatorcontrib><creatorcontrib>Karkhaneh, Akbar</creatorcontrib><title>On-demand release of ciprofloxacin from a smart nanofiber depot with acoustic stimulus</title><title>Journal of biosciences</title><addtitle>J Biosci</addtitle><addtitle>J Biosci</addtitle><description>Herein, an antibiotic-loaded electrospun scaffold with improved drug delivery via acoustic stimulation has been developed. Ultrasound stimulus with an intensity of 15 W/cm
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, duty-cycle of 50% and duration of 10 min was repeatedly applied to ciprofloxacin loaded alginate fibers. Ultrasonication with the aforesaid conditions increased drug release from scaffold probably due to disturbance of ionic crosslinks of alginate network. Scaffolds exposed to acoustic stimulus revealed higher antibacterial activity compared to those with no stimulus. Interestingly, antibiotic release radically increased and antibacterial function improved as ultrasound perturbed scaffold framework, but scaffold integrity was regained once the ultrasound probe was retracted.</description><subject>Acoustics</subject><subject>Alginates</subject><subject>Alginic acid</subject><subject>Antibacterial activity</subject><subject>Antibiotics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Ciprofloxacin</subject><subject>Crosslinking</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Drugs</subject><subject>Duration</subject><subject>Fibers</subject><subject>Frameworks</subject><subject>Life Sciences</subject><subject>Microbiology</subject><subject>Nanofibers</subject><subject>Plant Sciences</subject><subject>Scaffolds</subject><subject>Seaweed meal</subject><subject>Ultrasonic imaging</subject><subject>Ultrasound</subject><subject>Zoology</subject><issn>0250-5991</issn><issn>0973-7138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kE1vFiEURomxsbX6A9wYEjdu0HuHgYGlafxKmnRjuyUMXHSameEVZqL--9K8VRMTN0DCuQ8Ph7EXCG8QYHhbsQNpBKAR1oAR5hE7AztIMaA0j9u5UyCUtXjKntZ6C4C2l_CEnUpQPVqlz9jN1SoiLX6NvNBMvhLPiYfpUHKa808fppWnkhfueV182fjq15ymkQqPdMgb_zFt37gPea_bFHhbln3e6zN2kvxc6fnDfs6uP7z_cvFJXF59_Hzx7lIEOXSbiIhGBZl81KEnCT7GiCZBsGMgHSko6keplQbTqVGpYNGOOOgAkXRKvTxnr4-5re_3nermlqkGmme_UqvkOlTKgh4AG_rqH_Q272Vt7RqFWvVNiW4UHqlQcq2FkjuUqX38l0Nw99LdUbpr0t29dGfazMuH5H1cKP6Z-G25Ad0RqO1q_Url79P_T70D4KaNKg</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>Khorshidi, Sajedeh</creator><creator>Karkhaneh, Akbar</creator><general>Springer India</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H99</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.F</scope><scope>L.G</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20181201</creationdate><title>On-demand release of ciprofloxacin from a smart nanofiber depot with acoustic stimulus</title><author>Khorshidi, Sajedeh ; 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Ultrasound stimulus with an intensity of 15 W/cm
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, duty-cycle of 50% and duration of 10 min was repeatedly applied to ciprofloxacin loaded alginate fibers. Ultrasonication with the aforesaid conditions increased drug release from scaffold probably due to disturbance of ionic crosslinks of alginate network. Scaffolds exposed to acoustic stimulus revealed higher antibacterial activity compared to those with no stimulus. Interestingly, antibiotic release radically increased and antibacterial function improved as ultrasound perturbed scaffold framework, but scaffold integrity was regained once the ultrasound probe was retracted.</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>30541956</pmid><doi>10.1007/s12038-018-9808-8</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0250-5991 |
| ispartof | Journal of biosciences, 2018-12, Vol.43 (5), p.959-967 |
| issn | 0250-5991 0973-7138 |
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| source | Springer Online Journals Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Indian Academy of Sciences |
| subjects | Acoustics Alginates Alginic acid Antibacterial activity Antibiotics Biomedical and Life Sciences Biomedicine Cell Biology Ciprofloxacin Crosslinking Drug delivery Drug delivery systems Drugs Duration Fibers Frameworks Life Sciences Microbiology Nanofibers Plant Sciences Scaffolds Seaweed meal Ultrasonic imaging Ultrasound Zoology |
| title | On-demand release of ciprofloxacin from a smart nanofiber depot with acoustic stimulus |
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