NF1 regulates apoptosis in ovarian cancer cells by targeting MCL1 via miR-142-5p

loss confers chemoresistance in multiple cancers. However, the etiology remains largely unknown. Our study aimed to scrutinize the role of NF1 in chemoresistant ovarian cancer and its underlying mechanism. 4',6-diamidino-2-phenylindole staining, terminal deoxynucleotidyl transferase-mediated dU...

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Veröffentlicht in:	Pharmacogenomics 2019-02, Vol.20 (3), p.155-165
Hauptverfasser:	Su, Jiancheng, Ruan, Shaolin, Dai, Shengkun, Mi, Jing, Chen, Wei, Jiang, Songshan
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Binding sites Cell Line, Tumor Chemoresistance Chemotherapy Chromatin Cisplatin Cisplatin - adverse effects Cisplatin - pharmacology DNA nucleotidylexotransferase Drug Resistance, Neoplasm - genetics Etiology Female Gastric cancer Gene expression Gene Knockdown Techniques Humans Immunoprecipitation Kinases Liver cancer Lung cancer Mcl-1 protein MicroRNAs MicroRNAs - genetics miR-142-5p Myeloid Cell Leukemia Sequence 1 Protein - genetics Neurofibromin 1 - genetics Ovarian cancer Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Proteins
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