The role of tenascin-X in the uterosacral ligaments of postmenopausal women with pelvic organ prolapse: an immunohistochemical study
Introduction and hypothesis Abnormalities of connective tissue structure or its repair mechanism may predispose women to pelvic organ prolapse (POP). We hypothesized that the expression of tenascin-X in the uterosacral ligament of postmenopausal women with symptomatic POP is increased compared with...
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| Veröffentlicht in: | International Urogynecology Journal 2020, Vol.31 (1), p.101-106 |
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| container_title | International Urogynecology Journal |
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| creator | Bodner-Adler, Barbara Bodner, Klaus Kimberger, Oliver Halpern, Ksenia Schneidinger, Cora Haslinger, Peter Schneeberger, Christian Horvat, Reinhard Umek, Wolfgang |
| description | Introduction and hypothesis
Abnormalities of connective tissue structure or its repair mechanism may predispose women to pelvic organ prolapse (POP). We hypothesized that the expression of tenascin-X in the uterosacral ligament of postmenopausal women with symptomatic POP is increased compared with postmenopausal women without POP. Furthermore, we identified clinical risk factors associated with POP in our study population.
Methods
We conducted a retrospective case-control study in which 33 postmenopausal women with symptomatic POP ≥ pelvic organ prolapse quantification system (POP-Q) stage II were matched with 33 postmenopausal women without POP. Studied tissue specimens were taken from hysterectomy specimens, and tenascin-X expression was investigated by immunohistochemistry. The immunohistochemical profile of the uterosacral connective tissue of cases and controls was compared.
Results
Tenascin-X was expressed in 94% of POP cases and in 91% of controls. Our study failed to show any statistically significant differences in tenascin-X expression between women with and without POP (
p
= 0.64). However, tenascin-X was significantly more expressed in cases with severe prolapse (POP-Q stage IV) compared with moderate prolapse stages (POP-Q stage II and III) (
p
= 0.001). Advanced patient age as well as early menopausal age remained independent risk factors associated with POP in multiple logistic regression analysis (
p
= 0.001).
Conclusion
No difference could be demonstrated between tenascin-X expression in patients with or without POP. Tenascin-X does not seem to play a major role in the pathogenesis of POP in postmenopausal women. |
| doi_str_mv | 10.1007/s00192-018-3820-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2155169313</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2153840001</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-3e82cea93a60d9d1b0e84f984edbade35e7e6b54a941eeea8db2519bd35f7b433</originalsourceid><addsrcrecordid>eNp1kUFrFTEUhYMo9rX6A9xIwI2b6E0yeTNxJ0WrUHBTwV3IZO68lzKTjEnG0r0_3AyvKgiuwuV89-RyDiEvOLzhAO3bDMC1YMA7JjsBTDwiO95IySQI-ZjsQMuWyWYvzsh5zrcA0ICCp-RMgpJKt3pHft4ckaY4IY0jLRhsdj6wb9QHWqqyFkwxW5fsRCd_sDOGkjd0ibnUIS52zVW7i3Wgd74c6YLTD-9oTAcb6FKt7ZLxHa2Dn-c1xKPPJbojzt7VxVzW4f4ZeTLaKePzh_eCfP344ebyE7v-cvX58v01c7IVhUnshEOrpd3DoAfeA3bNqLsGh94OKBW2uO9VY3XDEdF2Qy8U1_0g1dj2NZcL8vrkW8_6vmIuZvbZ4TTZgHHNRnCl-F5LvqGv_kFv45pCvW6jZNfUMHml-IlyNaWccDRL8rNN94aD2Soyp4pMrchsFRlRd14-OK_9jMOfjd-dVECcgFylcMD09-v_u_4CBCqeyg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2153840001</pqid></control><display><type>article</type><title>The role of tenascin-X in the uterosacral ligaments of postmenopausal women with pelvic organ prolapse: an immunohistochemical study</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Bodner-Adler, Barbara ; Bodner, Klaus ; Kimberger, Oliver ; Halpern, Ksenia ; Schneidinger, Cora ; Haslinger, Peter ; Schneeberger, Christian ; Horvat, Reinhard ; Umek, Wolfgang</creator><creatorcontrib>Bodner-Adler, Barbara ; Bodner, Klaus ; Kimberger, Oliver ; Halpern, Ksenia ; Schneidinger, Cora ; Haslinger, Peter ; Schneeberger, Christian ; Horvat, Reinhard ; Umek, Wolfgang</creatorcontrib><description>Introduction and hypothesis
Abnormalities of connective tissue structure or its repair mechanism may predispose women to pelvic organ prolapse (POP). We hypothesized that the expression of tenascin-X in the uterosacral ligament of postmenopausal women with symptomatic POP is increased compared with postmenopausal women without POP. Furthermore, we identified clinical risk factors associated with POP in our study population.
Methods
We conducted a retrospective case-control study in which 33 postmenopausal women with symptomatic POP ≥ pelvic organ prolapse quantification system (POP-Q) stage II were matched with 33 postmenopausal women without POP. Studied tissue specimens were taken from hysterectomy specimens, and tenascin-X expression was investigated by immunohistochemistry. The immunohistochemical profile of the uterosacral connective tissue of cases and controls was compared.
Results
Tenascin-X was expressed in 94% of POP cases and in 91% of controls. Our study failed to show any statistically significant differences in tenascin-X expression between women with and without POP (
p
= 0.64). However, tenascin-X was significantly more expressed in cases with severe prolapse (POP-Q stage IV) compared with moderate prolapse stages (POP-Q stage II and III) (
p
= 0.001). Advanced patient age as well as early menopausal age remained independent risk factors associated with POP in multiple logistic regression analysis (
p
= 0.001).
Conclusion
No difference could be demonstrated between tenascin-X expression in patients with or without POP. Tenascin-X does not seem to play a major role in the pathogenesis of POP in postmenopausal women.</description><identifier>ISSN: 0937-3462</identifier><identifier>EISSN: 1433-3023</identifier><identifier>DOI: 10.1007/s00192-018-3820-2</identifier><identifier>PMID: 30535979</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Case-Control Studies ; Female ; Gynecology ; Health risk assessment ; Hormone replacement therapy ; Humans ; Immunohistochemistry ; Ligaments - metabolism ; Logistic Models ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Article ; Pelvic organ prolapse ; Pelvic Organ Prolapse - metabolism ; Postmenopause - metabolism ; Retrospective Studies ; Risk Factors ; Sacrum - metabolism ; Tenascin - metabolism ; Urology ; Uterus - metabolism</subject><ispartof>International Urogynecology Journal, 2020, Vol.31 (1), p.101-106</ispartof><rights>The International Urogynecological Association 2018</rights><rights>International Urogynecology Journal is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-3e82cea93a60d9d1b0e84f984edbade35e7e6b54a941eeea8db2519bd35f7b433</citedby><cites>FETCH-LOGICAL-c372t-3e82cea93a60d9d1b0e84f984edbade35e7e6b54a941eeea8db2519bd35f7b433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00192-018-3820-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00192-018-3820-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30535979$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bodner-Adler, Barbara</creatorcontrib><creatorcontrib>Bodner, Klaus</creatorcontrib><creatorcontrib>Kimberger, Oliver</creatorcontrib><creatorcontrib>Halpern, Ksenia</creatorcontrib><creatorcontrib>Schneidinger, Cora</creatorcontrib><creatorcontrib>Haslinger, Peter</creatorcontrib><creatorcontrib>Schneeberger, Christian</creatorcontrib><creatorcontrib>Horvat, Reinhard</creatorcontrib><creatorcontrib>Umek, Wolfgang</creatorcontrib><title>The role of tenascin-X in the uterosacral ligaments of postmenopausal women with pelvic organ prolapse: an immunohistochemical study</title><title>International Urogynecology Journal</title><addtitle>Int Urogynecol J</addtitle><addtitle>Int Urogynecol J</addtitle><description>Introduction and hypothesis
Abnormalities of connective tissue structure or its repair mechanism may predispose women to pelvic organ prolapse (POP). We hypothesized that the expression of tenascin-X in the uterosacral ligament of postmenopausal women with symptomatic POP is increased compared with postmenopausal women without POP. Furthermore, we identified clinical risk factors associated with POP in our study population.
Methods
We conducted a retrospective case-control study in which 33 postmenopausal women with symptomatic POP ≥ pelvic organ prolapse quantification system (POP-Q) stage II were matched with 33 postmenopausal women without POP. Studied tissue specimens were taken from hysterectomy specimens, and tenascin-X expression was investigated by immunohistochemistry. The immunohistochemical profile of the uterosacral connective tissue of cases and controls was compared.
Results
Tenascin-X was expressed in 94% of POP cases and in 91% of controls. Our study failed to show any statistically significant differences in tenascin-X expression between women with and without POP (
p
= 0.64). However, tenascin-X was significantly more expressed in cases with severe prolapse (POP-Q stage IV) compared with moderate prolapse stages (POP-Q stage II and III) (
p
= 0.001). Advanced patient age as well as early menopausal age remained independent risk factors associated with POP in multiple logistic regression analysis (
p
= 0.001).
Conclusion
No difference could be demonstrated between tenascin-X expression in patients with or without POP. Tenascin-X does not seem to play a major role in the pathogenesis of POP in postmenopausal women.</description><subject>Case-Control Studies</subject><subject>Female</subject><subject>Gynecology</subject><subject>Health risk assessment</subject><subject>Hormone replacement therapy</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Ligaments - metabolism</subject><subject>Logistic Models</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Pelvic organ prolapse</subject><subject>Pelvic Organ Prolapse - metabolism</subject><subject>Postmenopause - metabolism</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Sacrum - metabolism</subject><subject>Tenascin - metabolism</subject><subject>Urology</subject><subject>Uterus - metabolism</subject><issn>0937-3462</issn><issn>1433-3023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kUFrFTEUhYMo9rX6A9xIwI2b6E0yeTNxJ0WrUHBTwV3IZO68lzKTjEnG0r0_3AyvKgiuwuV89-RyDiEvOLzhAO3bDMC1YMA7JjsBTDwiO95IySQI-ZjsQMuWyWYvzsh5zrcA0ICCp-RMgpJKt3pHft4ckaY4IY0jLRhsdj6wb9QHWqqyFkwxW5fsRCd_sDOGkjd0ibnUIS52zVW7i3Wgd74c6YLTD-9oTAcb6FKt7ZLxHa2Dn-c1xKPPJbojzt7VxVzW4f4ZeTLaKePzh_eCfP344ebyE7v-cvX58v01c7IVhUnshEOrpd3DoAfeA3bNqLsGh94OKBW2uO9VY3XDEdF2Qy8U1_0g1dj2NZcL8vrkW8_6vmIuZvbZ4TTZgHHNRnCl-F5LvqGv_kFv45pCvW6jZNfUMHml-IlyNaWccDRL8rNN94aD2Soyp4pMrchsFRlRd14-OK_9jMOfjd-dVECcgFylcMD09-v_u_4CBCqeyg</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Bodner-Adler, Barbara</creator><creator>Bodner, Klaus</creator><creator>Kimberger, Oliver</creator><creator>Halpern, Ksenia</creator><creator>Schneidinger, Cora</creator><creator>Haslinger, Peter</creator><creator>Schneeberger, Christian</creator><creator>Horvat, Reinhard</creator><creator>Umek, Wolfgang</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>2020</creationdate><title>The role of tenascin-X in the uterosacral ligaments of postmenopausal women with pelvic organ prolapse: an immunohistochemical study</title><author>Bodner-Adler, Barbara ; Bodner, Klaus ; Kimberger, Oliver ; Halpern, Ksenia ; Schneidinger, Cora ; Haslinger, Peter ; Schneeberger, Christian ; Horvat, Reinhard ; Umek, Wolfgang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-3e82cea93a60d9d1b0e84f984edbade35e7e6b54a941eeea8db2519bd35f7b433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Case-Control Studies</topic><topic>Female</topic><topic>Gynecology</topic><topic>Health risk assessment</topic><topic>Hormone replacement therapy</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Ligaments - metabolism</topic><topic>Logistic Models</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Pelvic organ prolapse</topic><topic>Pelvic Organ Prolapse - metabolism</topic><topic>Postmenopause - metabolism</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Sacrum - metabolism</topic><topic>Tenascin - metabolism</topic><topic>Urology</topic><topic>Uterus - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bodner-Adler, Barbara</creatorcontrib><creatorcontrib>Bodner, Klaus</creatorcontrib><creatorcontrib>Kimberger, Oliver</creatorcontrib><creatorcontrib>Halpern, Ksenia</creatorcontrib><creatorcontrib>Schneidinger, Cora</creatorcontrib><creatorcontrib>Haslinger, Peter</creatorcontrib><creatorcontrib>Schneeberger, Christian</creatorcontrib><creatorcontrib>Horvat, Reinhard</creatorcontrib><creatorcontrib>Umek, Wolfgang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International Urogynecology Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bodner-Adler, Barbara</au><au>Bodner, Klaus</au><au>Kimberger, Oliver</au><au>Halpern, Ksenia</au><au>Schneidinger, Cora</au><au>Haslinger, Peter</au><au>Schneeberger, Christian</au><au>Horvat, Reinhard</au><au>Umek, Wolfgang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of tenascin-X in the uterosacral ligaments of postmenopausal women with pelvic organ prolapse: an immunohistochemical study</atitle><jtitle>International Urogynecology Journal</jtitle><stitle>Int Urogynecol J</stitle><addtitle>Int Urogynecol J</addtitle><date>2020</date><risdate>2020</risdate><volume>31</volume><issue>1</issue><spage>101</spage><epage>106</epage><pages>101-106</pages><issn>0937-3462</issn><eissn>1433-3023</eissn><abstract>Introduction and hypothesis
Abnormalities of connective tissue structure or its repair mechanism may predispose women to pelvic organ prolapse (POP). We hypothesized that the expression of tenascin-X in the uterosacral ligament of postmenopausal women with symptomatic POP is increased compared with postmenopausal women without POP. Furthermore, we identified clinical risk factors associated with POP in our study population.
Methods
We conducted a retrospective case-control study in which 33 postmenopausal women with symptomatic POP ≥ pelvic organ prolapse quantification system (POP-Q) stage II were matched with 33 postmenopausal women without POP. Studied tissue specimens were taken from hysterectomy specimens, and tenascin-X expression was investigated by immunohistochemistry. The immunohistochemical profile of the uterosacral connective tissue of cases and controls was compared.
Results
Tenascin-X was expressed in 94% of POP cases and in 91% of controls. Our study failed to show any statistically significant differences in tenascin-X expression between women with and without POP (
p
= 0.64). However, tenascin-X was significantly more expressed in cases with severe prolapse (POP-Q stage IV) compared with moderate prolapse stages (POP-Q stage II and III) (
p
= 0.001). Advanced patient age as well as early menopausal age remained independent risk factors associated with POP in multiple logistic regression analysis (
p
= 0.001).
Conclusion
No difference could be demonstrated between tenascin-X expression in patients with or without POP. Tenascin-X does not seem to play a major role in the pathogenesis of POP in postmenopausal women.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>30535979</pmid><doi>10.1007/s00192-018-3820-2</doi><tpages>6</tpages></addata></record> |
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| subjects | Case-Control Studies Female Gynecology Health risk assessment Hormone replacement therapy Humans Immunohistochemistry Ligaments - metabolism Logistic Models Medicine Medicine & Public Health Middle Aged Original Article Pelvic organ prolapse Pelvic Organ Prolapse - metabolism Postmenopause - metabolism Retrospective Studies Risk Factors Sacrum - metabolism Tenascin - metabolism Urology Uterus - metabolism |
| title | The role of tenascin-X in the uterosacral ligaments of postmenopausal women with pelvic organ prolapse: an immunohistochemical study |
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