Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing: Implications for the design of improved nanoantibiotics

Multidrug-resistant bacterial infections are a global health threat. Nanoparticles are thus investigated as novel antibacterial agents for clinical practice, including wound dressings and implants. We report that nanoparticles' bactericidal activity strongly depends on their physical binding to...

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Veröffentlicht in:	Biomaterials 2019-02, Vol.192, p.551-559
Hauptverfasser:	Siemer, Svenja, Westmeier, Dana, Barz, Matthias, Eckrich, Jonas, Wünsch, Désirée, Seckert, Christof, Thyssen, Christian, Schilling, Oliver, Hasenberg, Mike, Pang, Chengfang, Docter, Dominic, Knauer, Shirley K., Stauber, Roland H., Strieth, Sebastian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption Anti-Bacterial Agents - pharmacology Antibiotic nanomaterials Bacteria Biocorona Drug Resistance, Multiple, Bacterial - drug effects Escherichia coli - drug effects Escherichia coli - ultrastructure Implants Microbial Sensitivity Tests Microbial Viability - drug effects MRSA Multidrug-resistant pathogens Nanomedicine Nanoparticles Nanoparticles - chemistry Nanoparticles - ultrastructure Resistance
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