Caspase‑dependent apoptotic death by gadolinium chloride (GdCl3) via reactive oxygen species production and MAPK signaling in rat C6 glioma cells

Gadolinium (Gd) compounds serve as magnetic resonance imaging contrast agents and exert certain anticancer activities. Yet, the molecular signaling underlying the antitumor effect of Gd chloride (GdCl3) on glioma remains unclear. In the present study, we aimed to ascertain the apoptotic mechanisms o...

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Veröffentlicht in:	Oncology reports 2019-02, Vol.41 (2), p.1324-1332
Hauptverfasser:	Tsai, Yuh-Feng, Chen, Yuh-Fung, Hsiao, Chen-Yu, Huang, Ching-Wen, Lu, Chi-Cheng, Tsai, Shih-Chang, Yang, Jai-Sing
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Brain cancer Care and treatment Caspases Cell adhesion & migration Cell cycle Cell growth Cellular signal transduction Chemotherapy Contrast media Cytochrome Development and progression Gadolinium Genetic aspects Glioma Gliomas Health aspects Immunoglobulins Kinases Medical prognosis Membranes Mitochondria NMR Nuclear magnetic resonance Penicillin Phosphorylation Protein kinases Proteins Reactive oxygen species Tumor necrosis factor-TNF
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