Mutation screening of TP53, CHEK2 and BRCA genes in patients at high risk for hereditary breast and ovarian cancer (HBOC) in Brazil

Background Few studies related to hereditary breast and ovarian cancer syndrome (HBOC) have been conducted in Brazil, and they are restricted to only small areas of the country. Here, we report the mutation profile of BRCA1 / 2, CHEK2 and TP53 genes in a cohort from Minas Gerais state. Methods These...

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Veröffentlicht in:	Breast cancer (Tokyo, Japan) Japan), 2019-05, Vol.26 (3), p.397-405
Hauptverfasser:	Cipriano, Nilson Moreira, de Brito, Amanda Marques, de Oliveira, Eneida Santos, de Faria, Fabiana Castro, Lemos, Sara, Rodrigues, Angélica Nogueira, de Oliveira Lopes, Débora, dos Santos, Luciana Lara
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Brazil BRCA1 Protein - genetics BRCA2 Protein - genetics Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer Cancer Research Checkpoint Kinase 2 - genetics Cohort Studies Female Genes Genetic aspects Genetic Predisposition to Disease - genetics Hereditary Breast and Ovarian Cancer Syndrome - genetics Hereditary Breast and Ovarian Cancer Syndrome - pathology Humans Medicine Medicine & Public Health Middle Aged Mutation Oncology Oncology, Experimental Original Article Ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Surgery Surgical Oncology Tumor proteins Tumor Suppressor Protein p53 - genetics
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