microRNAs in cancer stem cells: Biology, pathways, and therapeutic opportunities

Cancer stem cells (CSCs) are a small subpopulation of tumor cells that have been identified in most types of cancer. Features that distinguish them from the bulk of tumor cells include their pluripotency, self‐renewal capacity, low proliferation rate, and tumor‐initiating ability. CSCs are highly ma...

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Veröffentlicht in:	Journal of cellular physiology 2019-07, Vol.234 (7), p.10002-10017
Hauptverfasser:	Asadzadeh, Zahra, Mansoori, Behzad, Mohammadi, Ali, Aghajani, Marjan, Haji‐Asgarzadeh, Khalil, Safarzadeh, Elham, Mokhtarzadeh, Ahad, Duijf, Pascal H. G., Baradaran, Behzad
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - therapeutic use Biology Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer cancer stem cells Cell proliferation Cell self-renewal Diagnostic systems Drug resistance Drug Resistance, Neoplasm Gene expression Gene Expression Regulation, Neoplastic Humans Metastases MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Molecular Diagnostic Techniques Molecular modelling Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Phenotype Pluripotency Post-transcription Predictive Value of Tests regulatory marker Ribonucleic acid RNA Signal Transduction signaling pathways Stem cells stemness Therapeutic targets Tumor cells Tumor suppressor genes Tumors Wnt protein
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