Microtubules: From understanding their dynamics to using them as potential therapeutic targets
Microtubules (MT) and actin microfilaments are dynamic cytoskeleton components involved in a range of intracellular processes. MTs play a role in cell division, beating of cilia and flagella, and intracellular transport. Over the past decades, much knowledge has been gained regarding MT function and...
Gespeichert in:
| Veröffentlicht in: | Journal of cellular physiology 2019-06, Vol.234 (6), p.7923-7937 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 7937 |
|---|---|
| container_issue | 6 |
| container_start_page | 7923 |
| container_title | Journal of cellular physiology |
| container_volume | 234 |
| creator | Ilan, Yaron |
| description | Microtubules (MT) and actin microfilaments are dynamic cytoskeleton components involved in a range of intracellular processes. MTs play a role in cell division, beating of cilia and flagella, and intracellular transport. Over the past decades, much knowledge has been gained regarding MT function and structure, and its role in underlying disease progression. This makes MT potential therapeutic targets for various disorders. Disturbances in MT and their associated proteins are the underlying cause of diseases such as Alzheimer’s disease, cancer, and several genetic diseases. Some of the advances in the field of MT research, as well as the potenti G beta gamma, is needed al uses of MT‐targeting agents in various conditions have been reviewed here. |
| doi_str_mv | 10.1002/jcp.27978 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2155157679</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2183984427</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3888-9c9df61e6379214cfd2a1f92cbfc8455b5f7b76cabef111a21e03788ed0164a3</originalsourceid><addsrcrecordid>eNp1kE1rFTEUQIMo9lld-Ack4KYups1NJpPEnTzaqrTURdcOmcydmsd8mQ_k_XtT36sLwdWFew-HyyHkLbBzYIxf7Nx6zpVR-hnZADOqqhvJn5NNuUFlZA0n5FWMO8aYMUK8JCeCSdEYCRvy_da7sKTc5RHjR3oVlonmuccQk517Pz_Q9AN9oP1-tpN3kaaF5njcT9RGui4J5-Tt-LgJdsWcvKPJhgdM8TV5Mdgx4pvjPCX3V5f328_Vzd31l-2nm8oJrXVlnOmHBrARynCo3dBzC4PhrhucrqXs5KA61Tjb4QAAlgMyobTGnkFTW3FKzg7aNSw_M8bUTj46HEc745Jjy0FKkKpRpqDv_0F3Sw5zea5QWhhd11wV6sOBKnFiDDi0a_CTDfsWWPvYvC3N2z_NC_vuaMzdhP1f8ilyAS4OwC8_4v7_pvbr9ttB-RuffowU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2183984427</pqid></control><display><type>article</type><title>Microtubules: From understanding their dynamics to using them as potential therapeutic targets</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Ilan, Yaron</creator><creatorcontrib>Ilan, Yaron</creatorcontrib><description>Microtubules (MT) and actin microfilaments are dynamic cytoskeleton components involved in a range of intracellular processes. MTs play a role in cell division, beating of cilia and flagella, and intracellular transport. Over the past decades, much knowledge has been gained regarding MT function and structure, and its role in underlying disease progression. This makes MT potential therapeutic targets for various disorders. Disturbances in MT and their associated proteins are the underlying cause of diseases such as Alzheimer’s disease, cancer, and several genetic diseases. Some of the advances in the field of MT research, as well as the potenti G beta gamma, is needed al uses of MT‐targeting agents in various conditions have been reviewed here.</description><identifier>ISSN: 0021-9541</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.27978</identifier><identifier>PMID: 30536951</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Actin ; Actin Cytoskeleton - genetics ; Alzheimer Disease - genetics ; Biological Transport - genetics ; Cancer ; Cell division ; Cell Division - genetics ; cell structure ; Cilia ; Cilia - genetics ; Cilia - metabolism ; Cytoplasm - genetics ; Cytoplasm - metabolism ; Cytoskeleton ; Cytoskeleton - genetics ; Cytoskeleton - metabolism ; Disease Progression ; Flagella ; Humans ; Intracellular ; Microfilaments ; Microtubules ; Microtubules - genetics ; Neoplasms - genetics ; Proteins ; Structure-function relationships ; Therapeutic applications</subject><ispartof>Journal of cellular physiology, 2019-06, Vol.234 (6), p.7923-7937</ispartof><rights>2018 The Authors. Published by Wiley Periodicals, Inc.</rights><rights>2018 The Authors. Journal of Cellular Physiology Published by Wiley Periodicals, Inc.</rights><rights>2018. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3888-9c9df61e6379214cfd2a1f92cbfc8455b5f7b76cabef111a21e03788ed0164a3</citedby><cites>FETCH-LOGICAL-c3888-9c9df61e6379214cfd2a1f92cbfc8455b5f7b76cabef111a21e03788ed0164a3</cites><orcidid>0000-0003-0802-1220</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcp.27978$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcp.27978$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30536951$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ilan, Yaron</creatorcontrib><title>Microtubules: From understanding their dynamics to using them as potential therapeutic targets</title><title>Journal of cellular physiology</title><addtitle>J Cell Physiol</addtitle><description>Microtubules (MT) and actin microfilaments are dynamic cytoskeleton components involved in a range of intracellular processes. MTs play a role in cell division, beating of cilia and flagella, and intracellular transport. Over the past decades, much knowledge has been gained regarding MT function and structure, and its role in underlying disease progression. This makes MT potential therapeutic targets for various disorders. Disturbances in MT and their associated proteins are the underlying cause of diseases such as Alzheimer’s disease, cancer, and several genetic diseases. Some of the advances in the field of MT research, as well as the potenti G beta gamma, is needed al uses of MT‐targeting agents in various conditions have been reviewed here.</description><subject>Actin</subject><subject>Actin Cytoskeleton - genetics</subject><subject>Alzheimer Disease - genetics</subject><subject>Biological Transport - genetics</subject><subject>Cancer</subject><subject>Cell division</subject><subject>Cell Division - genetics</subject><subject>cell structure</subject><subject>Cilia</subject><subject>Cilia - genetics</subject><subject>Cilia - metabolism</subject><subject>Cytoplasm - genetics</subject><subject>Cytoplasm - metabolism</subject><subject>Cytoskeleton</subject><subject>Cytoskeleton - genetics</subject><subject>Cytoskeleton - metabolism</subject><subject>Disease Progression</subject><subject>Flagella</subject><subject>Humans</subject><subject>Intracellular</subject><subject>Microfilaments</subject><subject>Microtubules</subject><subject>Microtubules - genetics</subject><subject>Neoplasms - genetics</subject><subject>Proteins</subject><subject>Structure-function relationships</subject><subject>Therapeutic applications</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kE1rFTEUQIMo9lld-Ack4KYups1NJpPEnTzaqrTURdcOmcydmsd8mQ_k_XtT36sLwdWFew-HyyHkLbBzYIxf7Nx6zpVR-hnZADOqqhvJn5NNuUFlZA0n5FWMO8aYMUK8JCeCSdEYCRvy_da7sKTc5RHjR3oVlonmuccQk517Pz_Q9AN9oP1-tpN3kaaF5njcT9RGui4J5-Tt-LgJdsWcvKPJhgdM8TV5Mdgx4pvjPCX3V5f328_Vzd31l-2nm8oJrXVlnOmHBrARynCo3dBzC4PhrhucrqXs5KA61Tjb4QAAlgMyobTGnkFTW3FKzg7aNSw_M8bUTj46HEc745Jjy0FKkKpRpqDv_0F3Sw5zea5QWhhd11wV6sOBKnFiDDi0a_CTDfsWWPvYvC3N2z_NC_vuaMzdhP1f8ilyAS4OwC8_4v7_pvbr9ttB-RuffowU</recordid><startdate>201906</startdate><enddate>201906</enddate><creator>Ilan, Yaron</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0802-1220</orcidid></search><sort><creationdate>201906</creationdate><title>Microtubules: From understanding their dynamics to using them as potential therapeutic targets</title><author>Ilan, Yaron</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3888-9c9df61e6379214cfd2a1f92cbfc8455b5f7b76cabef111a21e03788ed0164a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Actin</topic><topic>Actin Cytoskeleton - genetics</topic><topic>Alzheimer Disease - genetics</topic><topic>Biological Transport - genetics</topic><topic>Cancer</topic><topic>Cell division</topic><topic>Cell Division - genetics</topic><topic>cell structure</topic><topic>Cilia</topic><topic>Cilia - genetics</topic><topic>Cilia - metabolism</topic><topic>Cytoplasm - genetics</topic><topic>Cytoplasm - metabolism</topic><topic>Cytoskeleton</topic><topic>Cytoskeleton - genetics</topic><topic>Cytoskeleton - metabolism</topic><topic>Disease Progression</topic><topic>Flagella</topic><topic>Humans</topic><topic>Intracellular</topic><topic>Microfilaments</topic><topic>Microtubules</topic><topic>Microtubules - genetics</topic><topic>Neoplasms - genetics</topic><topic>Proteins</topic><topic>Structure-function relationships</topic><topic>Therapeutic applications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ilan, Yaron</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cellular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ilan, Yaron</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microtubules: From understanding their dynamics to using them as potential therapeutic targets</atitle><jtitle>Journal of cellular physiology</jtitle><addtitle>J Cell Physiol</addtitle><date>2019-06</date><risdate>2019</risdate><volume>234</volume><issue>6</issue><spage>7923</spage><epage>7937</epage><pages>7923-7937</pages><issn>0021-9541</issn><eissn>1097-4652</eissn><abstract>Microtubules (MT) and actin microfilaments are dynamic cytoskeleton components involved in a range of intracellular processes. MTs play a role in cell division, beating of cilia and flagella, and intracellular transport. Over the past decades, much knowledge has been gained regarding MT function and structure, and its role in underlying disease progression. This makes MT potential therapeutic targets for various disorders. Disturbances in MT and their associated proteins are the underlying cause of diseases such as Alzheimer’s disease, cancer, and several genetic diseases. Some of the advances in the field of MT research, as well as the potenti G beta gamma, is needed al uses of MT‐targeting agents in various conditions have been reviewed here.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30536951</pmid><doi>10.1002/jcp.27978</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0003-0802-1220</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-9541 |
| ispartof | Journal of cellular physiology, 2019-06, Vol.234 (6), p.7923-7937 |
| issn | 0021-9541 1097-4652 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2155157679 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Actin Actin Cytoskeleton - genetics Alzheimer Disease - genetics Biological Transport - genetics Cancer Cell division Cell Division - genetics cell structure Cilia Cilia - genetics Cilia - metabolism Cytoplasm - genetics Cytoplasm - metabolism Cytoskeleton Cytoskeleton - genetics Cytoskeleton - metabolism Disease Progression Flagella Humans Intracellular Microfilaments Microtubules Microtubules - genetics Neoplasms - genetics Proteins Structure-function relationships Therapeutic applications |
| title | Microtubules: From understanding their dynamics to using them as potential therapeutic targets |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T20%3A54%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Microtubules:%20From%20understanding%20their%20dynamics%20to%20using%20them%20as%20potential%20therapeutic%20targets&rft.jtitle=Journal%20of%20cellular%20physiology&rft.au=Ilan,%20Yaron&rft.date=2019-06&rft.volume=234&rft.issue=6&rft.spage=7923&rft.epage=7937&rft.pages=7923-7937&rft.issn=0021-9541&rft.eissn=1097-4652&rft_id=info:doi/10.1002/jcp.27978&rft_dat=%3Cproquest_cross%3E2183984427%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2183984427&rft_id=info:pmid/30536951&rfr_iscdi=true |