Precision Medicine and Advancing Clinical Care: Insights From Iceland

Despite an emphasis on clinical practice guidelines based on evidence from randomized clinical trials, medicine in many ways remains an inexact science. The limits of evidence-based medicine are apparent, including knowledge gaps from lack of high-quality clinical data. Moreover, the "one size...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Archives of internal medicine (1960) 2019-02, Vol.179 (2), p.139-140
Hauptverfasser: Arnar, David O, Palsson, Runolfur
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 140
container_issue 2
container_start_page 139
container_title Archives of internal medicine (1960)
container_volume 179
creator Arnar, David O
Palsson, Runolfur
description Despite an emphasis on clinical practice guidelines based on evidence from randomized clinical trials, medicine in many ways remains an inexact science. The limits of evidence-based medicine are apparent, including knowledge gaps from lack of high-quality clinical data. Moreover, the "one size fits all" strategy, designed for the average patient, is hampered by the biological variability that leads to heterogeneity in disease expression.
doi_str_mv 10.1001/jamainternmed.2018.6729
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2155156786</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><ama_id>2717955</ama_id><sourcerecordid>2155156786</sourcerecordid><originalsourceid>FETCH-LOGICAL-a306t-f8eaa761aafc2730832ef633cbe13ab55ed0a96d481264e86394b4885866ff973</originalsourceid><addsrcrecordid>eNpdkEtLw0AUhQdRbKn9Ay50wI2b1HlkHnFXQquFii50HSbJpE5JJnUmEfz3TugD9G7mDvc7h8MB4BajGUYIP2xVo4zttLONLmcEYTnjgiRnYEwwlxHHOD4_7YiPwNT7LQojEYopvQQjihiNE0HHYPHmdGG8aS180aUpjNVQ2RLOy29lw28D09pYU6gapsrpR7iy3mw-Ow-Xrm3gqtB1wK_ARaVqr6eHdwI-lov39Dlavz6t0vk6UhTxLqqkVkpwrFRVEEGRpERXnNIi15iqnDFdIpXwMpaY8FhLTpM4j6VkkvOqCnkn4H7vu3PtV699lzXGhwghg257nxHMGGZcBOUE3P1Dt23vbEgXKCmYIIIPhmJPFa713ukq2znTKPeTYZQNZWd_ys6GsrOh7KC8Ofj3-XA56o7VBuB6DwSD05UILBLG6C8vvIT2</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2187572767</pqid></control><display><type>article</type><title>Precision Medicine and Advancing Clinical Care: Insights From Iceland</title><source>MEDLINE</source><source>American Medical Association Journals</source><creator>Arnar, David O ; Palsson, Runolfur</creator><creatorcontrib>Arnar, David O ; Palsson, Runolfur</creatorcontrib><description>Despite an emphasis on clinical practice guidelines based on evidence from randomized clinical trials, medicine in many ways remains an inexact science. The limits of evidence-based medicine are apparent, including knowledge gaps from lack of high-quality clinical data. Moreover, the "one size fits all" strategy, designed for the average patient, is hampered by the biological variability that leads to heterogeneity in disease expression.</description><identifier>ISSN: 2168-6106</identifier><identifier>EISSN: 2168-6114</identifier><identifier>DOI: 10.1001/jamainternmed.2018.6729</identifier><identifier>PMID: 30534973</identifier><language>eng</language><publisher>United States: American Medical Association</publisher><subject>Clinical medicine ; Clinical trials ; Evidence-based medicine ; General Practitioners - organization &amp; administration ; Humans ; Iceland ; Point-of-Care Testing - standards ; Precision medicine ; Precision Medicine - standards ; Primary Health Care - standards</subject><ispartof>Archives of internal medicine (1960), 2019-02, Vol.179 (2), p.139-140</ispartof><rights>Copyright American Medical Association Feb 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-a306t-f8eaa761aafc2730832ef633cbe13ab55ed0a96d481264e86394b4885866ff973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jamanetwork.com/journals/jamainternalmedicine/articlepdf/10.1001/jamainternmed.2018.6729$$EPDF$$P50$$Gama$$H</linktopdf><linktohtml>$$Uhttps://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/jamainternmed.2018.6729$$EHTML$$P50$$Gama$$H</linktohtml><link.rule.ids>64,314,776,780,3326,27903,27904,76235,76238</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30534973$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arnar, David O</creatorcontrib><creatorcontrib>Palsson, Runolfur</creatorcontrib><title>Precision Medicine and Advancing Clinical Care: Insights From Iceland</title><title>Archives of internal medicine (1960)</title><addtitle>JAMA Intern Med</addtitle><description>Despite an emphasis on clinical practice guidelines based on evidence from randomized clinical trials, medicine in many ways remains an inexact science. The limits of evidence-based medicine are apparent, including knowledge gaps from lack of high-quality clinical data. Moreover, the "one size fits all" strategy, designed for the average patient, is hampered by the biological variability that leads to heterogeneity in disease expression.</description><subject>Clinical medicine</subject><subject>Clinical trials</subject><subject>Evidence-based medicine</subject><subject>General Practitioners - organization &amp; administration</subject><subject>Humans</subject><subject>Iceland</subject><subject>Point-of-Care Testing - standards</subject><subject>Precision medicine</subject><subject>Precision Medicine - standards</subject><subject>Primary Health Care - standards</subject><issn>2168-6106</issn><issn>2168-6114</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtLw0AUhQdRbKn9Ay50wI2b1HlkHnFXQquFii50HSbJpE5JJnUmEfz3TugD9G7mDvc7h8MB4BajGUYIP2xVo4zttLONLmcEYTnjgiRnYEwwlxHHOD4_7YiPwNT7LQojEYopvQQjihiNE0HHYPHmdGG8aS180aUpjNVQ2RLOy29lw28D09pYU6gapsrpR7iy3mw-Ow-Xrm3gqtB1wK_ARaVqr6eHdwI-lov39Dlavz6t0vk6UhTxLqqkVkpwrFRVEEGRpERXnNIi15iqnDFdIpXwMpaY8FhLTpM4j6VkkvOqCnkn4H7vu3PtV699lzXGhwghg257nxHMGGZcBOUE3P1Dt23vbEgXKCmYIIIPhmJPFa713ukq2znTKPeTYZQNZWd_ys6GsrOh7KC8Ofj3-XA56o7VBuB6DwSD05UILBLG6C8vvIT2</recordid><startdate>20190201</startdate><enddate>20190201</enddate><creator>Arnar, David O</creator><creator>Palsson, Runolfur</creator><general>American Medical Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20190201</creationdate><title>Precision Medicine and Advancing Clinical Care: Insights From Iceland</title><author>Arnar, David O ; Palsson, Runolfur</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a306t-f8eaa761aafc2730832ef633cbe13ab55ed0a96d481264e86394b4885866ff973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Clinical medicine</topic><topic>Clinical trials</topic><topic>Evidence-based medicine</topic><topic>General Practitioners - organization &amp; administration</topic><topic>Humans</topic><topic>Iceland</topic><topic>Point-of-Care Testing - standards</topic><topic>Precision medicine</topic><topic>Precision Medicine - standards</topic><topic>Primary Health Care - standards</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arnar, David O</creatorcontrib><creatorcontrib>Palsson, Runolfur</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of internal medicine (1960)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arnar, David O</au><au>Palsson, Runolfur</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Precision Medicine and Advancing Clinical Care: Insights From Iceland</atitle><jtitle>Archives of internal medicine (1960)</jtitle><addtitle>JAMA Intern Med</addtitle><date>2019-02-01</date><risdate>2019</risdate><volume>179</volume><issue>2</issue><spage>139</spage><epage>140</epage><pages>139-140</pages><issn>2168-6106</issn><eissn>2168-6114</eissn><abstract>Despite an emphasis on clinical practice guidelines based on evidence from randomized clinical trials, medicine in many ways remains an inexact science. The limits of evidence-based medicine are apparent, including knowledge gaps from lack of high-quality clinical data. Moreover, the "one size fits all" strategy, designed for the average patient, is hampered by the biological variability that leads to heterogeneity in disease expression.</abstract><cop>United States</cop><pub>American Medical Association</pub><pmid>30534973</pmid><doi>10.1001/jamainternmed.2018.6729</doi><tpages>2</tpages></addata></record>
fulltext fulltext
identifier ISSN: 2168-6106
ispartof Archives of internal medicine (1960), 2019-02, Vol.179 (2), p.139-140
issn 2168-6106
2168-6114
language eng
recordid cdi_proquest_miscellaneous_2155156786
source MEDLINE; American Medical Association Journals
subjects Clinical medicine
Clinical trials
Evidence-based medicine
General Practitioners - organization & administration
Humans
Iceland
Point-of-Care Testing - standards
Precision medicine
Precision Medicine - standards
Primary Health Care - standards
title Precision Medicine and Advancing Clinical Care: Insights From Iceland
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T14%3A05%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Precision%20Medicine%20and%20Advancing%20Clinical%20Care:%20Insights%20From%20Iceland&rft.jtitle=Archives%20of%20internal%20medicine%20(1960)&rft.au=Arnar,%20David%20O&rft.date=2019-02-01&rft.volume=179&rft.issue=2&rft.spage=139&rft.epage=140&rft.pages=139-140&rft.issn=2168-6106&rft.eissn=2168-6114&rft_id=info:doi/10.1001/jamainternmed.2018.6729&rft_dat=%3Cproquest_cross%3E2155156786%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2187572767&rft_id=info:pmid/30534973&rft_ama_id=2717955&rfr_iscdi=true