MDSC; the Most Important Cell You Have Never Heard Of

MDSC; the Most Important Cell You Have Never Heard Of

The myeloid-derived suppressor cell (MDSC) is the ‘queen bee’ of the tumor microenvironment. MDSCs protect the cancer from the patient’s immune system, make the tumor resistant to immunotherapy, and allow the tumor to thrive while the patient withers away. Eliminating MDSCs should improve response r...

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Veröffentlicht in:Trends in pharmacological sciences (Regular ed.) 2019-01, Vol.40 (1), p.4-7
1. Verfasser: Tesi, R.J.
Format: Artikel
Sprache:eng
Schlagworte:
cancer therapy
myeloid-derived suppressor cell
tumor microenvironment
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Zusammenfassung:The myeloid-derived suppressor cell (MDSC) is the ‘queen bee’ of the tumor microenvironment. MDSCs protect the cancer from the patient’s immune system, make the tumor resistant to immunotherapy, and allow the tumor to thrive while the patient withers away. Eliminating MDSCs should improve response rates to cancer therapy and patient survival.
ISSN:0165-6147
1873-3735
DOI:10.1016/j.tips.2018.10.008