Autophagy in the renewal, differentiation and homeostasis of immune cells
Across all branches of the immune system, the process of autophagy is fundamentally important in cellular development, function and homeostasis. Strikingly, this evolutionarily ancient pathway for intracellular recycling has been adapted to enable a high degree of functional complexity and specializ...
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| Veröffentlicht in: | Nature reviews. Immunology 2019-03, Vol.19 (3), p.170-183 |
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| container_title | Nature reviews. Immunology |
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| creator | Clarke, Alexander J. Simon, Anna Katharina |
| description | Across all branches of the immune system, the process of autophagy is fundamentally important in cellular development, function and homeostasis. Strikingly, this evolutionarily ancient pathway for intracellular recycling has been adapted to enable a high degree of functional complexity and specialization. However, although the requirement for autophagy in normal immune cell function is clear, the mechanisms involved are much less so and encompass control of metabolism, selective degradation of substrates and organelles and participation in cell survival decisions. We review here the crucial functions of autophagy in controlling the differentiation and homeostasis of multiple immune cell types and discuss the potential mechanisms involved.
This Review discusses the importance of autophagy in controlling immune cell differentiation and homeostasis. The authors consider the diverse mechanisms through which autophagy functions to shape the immune system, highlighting its role in the dynamic regulation of metabolism. |
| doi_str_mv | 10.1038/s41577-018-0095-2 |
| format | Article |
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This Review discusses the importance of autophagy in controlling immune cell differentiation and homeostasis. The authors consider the diverse mechanisms through which autophagy functions to shape the immune system, highlighting its role in the dynamic regulation of metabolism.</description><subject>42/41</subject><subject>631/250/2152/1566/2493</subject><subject>631/250/232/2058</subject><subject>631/250/2504</subject><subject>631/80/39</subject><subject>Autophagy</subject><subject>Autophagy (Cytology)</subject><subject>Autophagy - immunology</subject><subject>Autophagy - physiology</subject><subject>B-Lymphocytes - cytology</subject><subject>B-Lymphocytes - immunology</subject><subject>B-Lymphocytes - physiology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell differentiation</subject><subject>Cell Differentiation - physiology</subject><subject>Cell survival</subject><subject>Health aspects</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunology</subject><subject>Lymphocytes - cytology</subject><subject>Lymphocytes - immunology</subject><subject>Lymphocytes - physiology</subject><subject>Medical research</subject><subject>Myeloid Cells - cytology</subject><subject>Myeloid Cells - immunology</subject><subject>Myeloid Cells - physiology</subject><subject>Observations</subject><subject>Organelles</subject><subject>Phagocytosis</subject><subject>Review Article</subject><subject>Specialization</subject><subject>T-Lymphocytes - cytology</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - physiology</subject><issn>1474-1733</issn><issn>1474-1741</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1ktuL1DAUxoMo7jr6B_giBUEU7JqTSzN9HBYvAwuCl-eQtifTLG0yNinr_vemzrg6ouQhl_P7Pk4OHyFPgV4A5es3UYBUqqSwLimtZcnukXMQSpSgBNy_O3N-Rh7FeE0pVLnykJxxKjnUgp-T7WZOYd-b3W3hfJF6LCb0eGOG10XnrMV8S84kF3xhfFf0YcQQk4kuFsEWbhxnj0WLwxAfkwfWDBGfHPcV-fru7ZfLD-XVx_fby81V2UpFU8kAsKFCqrqClgkp6lp2laWdbWvWKLTCdI2t2kbJrumMbIXkGbNKsLqqQfAVeXnw3U_h24wx6dHFpQPjMcxRM5ASJLD87RV5_hd6HebJ5-4ytZbrCvhPwyO1MwNq521Ik2kXU72RStZcMVll6uIfVF4djq4NHq3L7yeCVyeCzCT8nnZmjlFvP386ZV_8wfZohtTHMMzL3OMpCAewnUKME1q9n9xoplsNVC-Z0IdM6JwJvWRCs6x5dpzC3IzY3Sl-hSAD7ADEXPI7nH6P6f-uPwC-H7zs</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Clarke, Alexander J.</creator><creator>Simon, Anna Katharina</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QR</scope><scope>7RV</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2846-7860</orcidid></search><sort><creationdate>20190301</creationdate><title>Autophagy in the renewal, differentiation and homeostasis of immune cells</title><author>Clarke, Alexander J. ; Simon, Anna Katharina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c570t-211eb0457961c2454995d6f0dfc92b7ef4adbf6cb75dbda5c453245f742969143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>42/41</topic><topic>631/250/2152/1566/2493</topic><topic>631/250/232/2058</topic><topic>631/250/2504</topic><topic>631/80/39</topic><topic>Autophagy</topic><topic>Autophagy (Cytology)</topic><topic>Autophagy - immunology</topic><topic>Autophagy - physiology</topic><topic>B-Lymphocytes - cytology</topic><topic>B-Lymphocytes - immunology</topic><topic>B-Lymphocytes - physiology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell differentiation</topic><topic>Cell Differentiation - physiology</topic><topic>Cell survival</topic><topic>Health aspects</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunology</topic><topic>Lymphocytes - cytology</topic><topic>Lymphocytes - immunology</topic><topic>Lymphocytes - physiology</topic><topic>Medical research</topic><topic>Myeloid Cells - cytology</topic><topic>Myeloid Cells - immunology</topic><topic>Myeloid Cells - physiology</topic><topic>Observations</topic><topic>Organelles</topic><topic>Phagocytosis</topic><topic>Review Article</topic><topic>Specialization</topic><topic>T-Lymphocytes - cytology</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Clarke, Alexander J.</creatorcontrib><creatorcontrib>Simon, Anna Katharina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Nature reviews. Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Clarke, Alexander J.</au><au>Simon, Anna Katharina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Autophagy in the renewal, differentiation and homeostasis of immune cells</atitle><jtitle>Nature reviews. Immunology</jtitle><stitle>Nat Rev Immunol</stitle><addtitle>Nat Rev Immunol</addtitle><date>2019-03-01</date><risdate>2019</risdate><volume>19</volume><issue>3</issue><spage>170</spage><epage>183</epage><pages>170-183</pages><issn>1474-1733</issn><eissn>1474-1741</eissn><abstract>Across all branches of the immune system, the process of autophagy is fundamentally important in cellular development, function and homeostasis. Strikingly, this evolutionarily ancient pathway for intracellular recycling has been adapted to enable a high degree of functional complexity and specialization. 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This Review discusses the importance of autophagy in controlling immune cell differentiation and homeostasis. The authors consider the diverse mechanisms through which autophagy functions to shape the immune system, highlighting its role in the dynamic regulation of metabolism.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30531943</pmid><doi>10.1038/s41577-018-0095-2</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-2846-7860</orcidid></addata></record> |
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| subjects | 42/41 631/250/2152/1566/2493 631/250/232/2058 631/250/2504 631/80/39 Autophagy Autophagy (Cytology) Autophagy - immunology Autophagy - physiology B-Lymphocytes - cytology B-Lymphocytes - immunology B-Lymphocytes - physiology Biomedical and Life Sciences Biomedicine Cell differentiation Cell Differentiation - physiology Cell survival Health aspects Homeostasis Humans Immune response Immune system Immunology Lymphocytes - cytology Lymphocytes - immunology Lymphocytes - physiology Medical research Myeloid Cells - cytology Myeloid Cells - immunology Myeloid Cells - physiology Observations Organelles Phagocytosis Review Article Specialization T-Lymphocytes - cytology T-Lymphocytes - immunology T-Lymphocytes - physiology |
| title | Autophagy in the renewal, differentiation and homeostasis of immune cells |
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