A PALB2 truncating mutation: Implication in cancer prevention and therapy of Hereditary Breast and Ovarian Cancer

Explaining genetic predisposition in Hereditary Breast and Ovarian Cancer (HBOC) families without BRCA mutations is crucial. Germline PALB2 inactivating mutations were associated with an increased risk of HBOC due to its role in DNA repair through cooperation with BRCA proteins. The prevalence and p...

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Veröffentlicht in:	Breast (Edinburgh) 2019-02, Vol.43, p.91-96
Hauptverfasser:	Velázquez, Carolina, Esteban-Cardeñosa, Eva M., Lastra, Enrique, Abella, Luis E., de la Cruz, Virginia, Lobatón, Carmen D., Durán, Mercedes, Infante, Mar
Format:	Artikel
Sprache:	eng
Schlagworte:	Germline mutations Hereditary Breast and Ovarian Cancer Mutation screening PALB2
Online-Zugang:	Volltext
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