Catalytic Geminal Difluorination of Styrenes for the Construction of Fluorine-rich Bioisosteres

A geminal difluorination of alkenes based on I­(I)/I­(III) catalysis is disclosed, which is compatible with a range of electronically and substitutionally diverse styrenes (27 examples, up to 89% yield). Employing inexpensive p-TolI as the organocatalyst, turnover is enabled by Selectfluor-mediated...

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Veröffentlicht in:	Organic letters 2018-12, Vol.20 (24), p.8073-8076
Hauptverfasser:	Scheidt, Felix, Neufeld, Jessica, Schäfer, Michael, Thiehoff, Christian, Gilmour, Ryan
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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