Isoform selective PLD inhibition by novel, chiral 2,8-diazaspiro[4.5]decan-1-one derivatives

[Display omitted] •A novel 2,8-diazaspiro[4.5]decan-1-one core affords enantioselective inhibition of PLD enzymes.•A single chemotype can produce PLD1, PLD2 and dual PLD1/PLD2 inhibitors.•The new series afford improvements in protein binding, predicted clearance and half-life in vivo.•Novelty allowe...

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