Bortezomib restores stroma-mediated APO2L/TRAIL apoptosis resistance in multiple myeloma

Objectives: Hematopoietic stroma promotes resistance to immune control by APO2L/TRAIL in multiple myeloma (MM) cells in part by increasing synthesis of the anti‐apoptotic protein c‐FLIP. Here, we tested whether bortezomib can reverse the APO2L/TRAIL environmental mediated‐immune resistance (EM‐IR)....

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Veröffentlicht in:	European journal of haematology 2010-03, Vol.84 (3), p.212-222
Hauptverfasser:	Perez, Lia E., Parquet, Nancy, Meads, Mark, Anasetti, Claudio, Dalton, William
Format:	Artikel
Sprache:	eng
Schlagworte:	APO2L apoptosis Apoptosis - drug effects Boronic Acids - pharmacology Boronic Acids - therapeutic use Bortezomib CASP8 and FADD-Like Apoptosis Regulating Protein - antagonists & inhibitors Cell Line, Tumor - drug effects Cells, Cultured - drug effects Cells, Cultured - secretion Coculture Techniques Cytokines - biosynthesis Cytokines - genetics Drug Screening Assays, Antitumor Drug Synergism Gene Expression Regulation, Neoplastic - drug effects Humans multiple myeloma Multiple Myeloma - pathology Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Protease Inhibitors - pharmacology Protease Inhibitors - therapeutic use Pyrazines - pharmacology Pyrazines - therapeutic use Receptors, TNF-Related Apoptosis-Inducing Ligand - antagonists & inhibitors Receptors, TNF-Related Apoptosis-Inducing Ligand - physiology Receptors, Tumor Necrosis Factor - antagonists & inhibitors Receptors, Tumor Necrosis Factor - physiology Recombinant Proteins - pharmacology stroma Stromal Cells - drug effects Stromal Cells - secretion TNF-Related Apoptosis-Inducing Ligand - pharmacology TNF-Related Apoptosis-Inducing Ligand - physiology TRAIL Tumor Escape - drug effects
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