Characterization of specific CD4 and CD8 T-cell responses in QuantiFERON TB Gold-Plus TB1 and TB2 tubes

The new generation of the IGRA QuantiFERON-TB Gold Plus (QFT-Plus) includes two antigen tubes, TB1 and TB2 which contain specific Mycobacterium tuberculosis peptides designed to stimulate both CD4 and CD8 T-cells. TB1 is designed to target cell mediated responses from CD4 T-cells, while TB2 contains...

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Veröffentlicht in:	Tuberculosis (Edinburgh, Scotland) Scotland), 2018-12, Vol.113, p.239-241
Hauptverfasser:	Allen, Nadia PC, Swarbrick, Gwendolyn, Cansler, Meghan, Null, Megan, Salim, Hiam, Miyamasu, Misato, Howard, Jenny, Boyle, Jeffrey, Lewinsohn, David, Lewinsohn, Deborah
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - immunology CD4 antigen CD4 T-cell responses CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - microbiology CD8 antigen CD8 T-cell responses CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - microbiology Cells CFP-10 protein Enzyme-Linked Immunosorbent Assay Equipment Design Gold Host-Pathogen Interactions Humans Immunodominant Epitopes Interferon Interferon-gamma - immunology Interferon-gamma Release Tests - instrumentation Lymphocytes T Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis - pathogenicity Peptides Predictive Value of Tests Proteins QFT-Plus QuantiFERON Reproducibility of Results Tuberculosis Tuberculosis (TB) Tuberculosis - diagnosis Tuberculosis - immunology Tuberculosis - microbiology Tubes γ-Interferon
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