Promoter DNA Methylation and mRNA Expression Level of p16 Gene in Oral Squamous Cell Carcinoma: Correlation with Clinicopathological Characteristics

The aim of this study was to investigate the relationship between p16 methylation and its expression in oral squamous cell carcinoma (OSCC). Also the contribution of clinicopathological factors, HPV infection and smoking in p16 expression and promoter methylation has been investigated. In this study...

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Veröffentlicht in:	Pathology oncology research 2019-10, Vol.25 (4), p.1535-1543
Hauptverfasser:	Allameh, Abdolamir, Moazeni-Roodi, Abdolkarim, Harirchi, Iraj, Ravanshad, Mehrdad, Motiee-Langroudi, Maziar, Garajei, Ata, Hamidavi, Azin, Mesbah-Namin, Seyed Alireza
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - virology Case-Control Studies Cyclin-Dependent Kinase Inhibitor p16 - genetics Cyclin-Dependent Kinase Inhibitor p16 - metabolism Dentistry Deoxyribonucleic acid DNA DNA Methylation Environmental factors Female Follow-Up Studies Gene expression Gene Expression Regulation, Neoplastic Human papillomavirus Humans Immunology Infections Male Middle Aged Mouth Neoplasms - genetics Mouth Neoplasms - metabolism Mouth Neoplasms - pathology Oncology Oral cancer Oral cavity Oral squamous cell carcinoma Original Article p16 Protein Papillomaviridae - isolation & purification Papillomavirus Infections - complications Papillomavirus Infections - virology Pathology Patients Polymerase chain reaction Prognosis Promoter Regions, Genetic Smoking Squamous cell carcinoma Surgery Tissues Tumors
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