$Distribution of platinum between nuclear and cytosolic fractions – Can subcellular fractionation be performed quantitatively?$

Distribution of platinum between nuclear and cytosolic fractions – Can subcellular fractionation be performed quantitatively?

[Display omitted] •Cisplatin-exposed cells were fractionated into cytosol and nuclei.•Obtained nuclei were not contaminated with cytosol and vice versa.•18% and 66% of Pt taken up by cells were located in nuclei and cytosol respectively.•Accumulated uncertainty and fraction purity had a negative eff...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2019-02, Vol.165, p.82-89
Hauptverfasser:	Dam, Celina Støving, Lambert, Ian Henry, Gammelgaard, Bente, Stürup, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Cisplatin Inductively coupled plasma mass spectrometry Quantitative Subcellular distribution Subcellular fractionation
Online-Zugang:	Volltext
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