17B-hydroxysteroid dehydrogenases as acyl thioester metabolizing enzymes

17β-Hydroxysteroid dehydrogenases (HSD17B) catalyze the oxidation/reduction of 17β-hydroxy/keto group in position C17 in C18- and C19 steroids. Most HSD17Bs are also catalytically active with substrates other than steroids. A subset of these enzymes is able to process thioesters of carboxylic acids....

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Veröffentlicht in:	Molecular and cellular endocrinology 2019-06, Vol.489, p.107-118
Hauptverfasser:	Hiltunen, J. Kalervo, Kastaniotis, Alexander J., Autio, Kaija J., Jiang, Guangyu, Chen, Zhijun, Glumoff, Tuomo
Format:	Artikel
Sprache:	eng
Schlagworte:	17-Hydroxysteroid Dehydrogenases - chemistry 17-Hydroxysteroid Dehydrogenases - metabolism 17β-Hydroxysteroids Animals Disease Esters - metabolism Fatty acid synthesis Fatty Acids, Unsaturated - metabolism Fatty acyl thioesters Humans Lipid metabolism Mitochondria - metabolism Multifunctional proteins RNA - metabolism RNase P β-Oxidation
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