Prodrugs of the cancer cell selective anti-cancer agent (Z)-2-(1H-indol-3-yl)-3-(isoquinolin-5-yl)acrylonitrile (A131) are orally efficacious in a mouse model of resistant colon cancer

[Display omitted] •A131 possesses a unique cancer cell selective dual mechanism of action.•Prodrugs based on modification of the indole nitrogen of 1 undergo degradation to the parent drug in plasma.•Preferred prodrugs fully elicited the pharmacological effects of 1 in cells.•Preferred prodrugs and...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2019-01, Vol.29 (2), p.216-219
Hauptverfasser:	See, Cheng Shang, Kitagawa, Mayumi, Liao, Pei-Ju, Lee, Kyung Hee, Wong, Jasmine, Lee, Sang Hyun, Dymock, Brian W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimitotic Antiproliferative Antitumor Prodrug Tumor-selective
Online-Zugang:	Volltext
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