Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids

The mammalian liver possesses a remarkable regenerative ability. Two modes of damage response have been described: (1) The “oval cell” response emanates from the biliary tree when all hepatocytes are affected by chronic liver disease. (2) A massive, proliferative response of mature hepatocytes occur...

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Veröffentlicht in:	Cell 2018-11, Vol.175 (6), p.1591-1606.e19
Hauptverfasser:	Hu, Huili, Gehart, Helmuth, Artegiani, Benedetta, LÖpez-Iglesias, Carmen, Dekkers, Florijn, Basak, Onur, van Es, Johan, Chuva de Sousa Lopes, Susana M., Begthel, Harry, Korving, Jeroen, van den Born, Maaike, Zou, Chenhui, Quirk, Corrine, Chiriboga, Luis, Rice, Charles M., Ma, Stephanie, Rios, Anne, Peters, Peter J., de Jong, Ype P., Clevers, Hans
Format:	Artikel
Sprache:	eng
Schlagworte:	Hepatocyte Organoid Hepatocyte Proliferation Human Liver Organoid Liver Regeneration
Online-Zugang:	Volltext
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