Metal‐Free Dearomatization: Direct Access to Spiroindol(en)ines in Batch and Continuous‐Flow

A metal‐free, phosphine‐catalyzed intramolecular “umpolung Michael addition” on alkynes to form spiroindol(en)ines is reported. This nucleophilic catalysis enables the formation of a wide scope of five‐ and six‐membered spiroindol(en)ines in moderate to excellent yields in batch as well as under con...

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Veröffentlicht in:	Chemistry : a European journal 2019-02, Vol.25 (10), p.2442-2446
Hauptverfasser:	Ranjan, Prabhat, Ojeda, Gerardo M., Sharma, Upendra K., Van der Eycken, Erik V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes Catalysis Chemistry dearomatization flow chemistry indoles organocatalysis Phosphine spiroindolenine
Online-Zugang:	Volltext
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