Synthesis of novel guttiferone E and xanthochymol derivatives with cytotoxicities by inducing cell apoptosis and arresting the cell cycle phase

The mixture of GX (guttiferone E and xanthochymol), an inseparable polycyclic polyprenylated acylphloroglucinol (PPAP), showed moderate cytotoxic activities. The chemical transformation of GX yielded three different types of PPAPs (1, 2, and 3/4). A series of analogs were prepared, and the structure...

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Veröffentlicht in:	European journal of medicinal chemistry 2019-01, Vol.162, p.765-780
Hauptverfasser:	Lin, Xin, Tian, Dongsong, Fu, Yanhui, Li, Yanan, Huang, Liejun, Gu, Wei, Song, Jialei, Li, Yanmei, Ben-David, Yaacov, Wen, Min, Yuan, Chunmao, Hao, Xiaojiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell apoptosis Cell cycle arrest Chemical transformation Cytotoxicity Polycyclic polyprenylated acylphloroglucinol
Online-Zugang:	Volltext
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