Eryptosis of non-parasitized erythrocytes is related to anemia in Plasmodium berghei low parasitema malaria of Wistar rats
It is known that premature elimination of non-parasitized RBCs (nRBCs) plays an important role in the pathogenesis of malarial anemia, in which suicidal death process (eryptosis) of nRBCs has been suggested to be involved. To check this possibility, we investigate eryptosis during infection of P. be...
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container_title | Parasitology research (1987) |
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creator | Totino, Paulo Renato Rivas de Souza, Hugo Amorim dos Santos Correa, Edmar Henrique Costa Daniel-Ribeiro, Cláudio Tadeu Ferreira-da-Cruz, Maria de Fátima |
description | It is known that premature elimination of non-parasitized RBCs (nRBCs) plays an important role in the pathogenesis of malarial anemia, in which suicidal death process (eryptosis) of nRBCs has been suggested to be involved. To check this possibility, we investigate eryptosis during infection of
P. berghei
ANKA in Wistar rats, a malaria experimental model that, similar to human malaria, the infection courses with low parasitemia and acute anemia. As expected,
P. berghei
ANKA infection was marked by low parasite burdens that reached a mean peak of 3% between days six and nine post-infection and solved spontaneously. A significant reduction of the hemoglobin levels (~ 30%) was also observed on days subsequent to the peak of parasitemia, persisting until day 16 post-infection. In eryptosis assays, it was observed a significant increase in the levels of PS-exposing nRBC, which coincided with the reduction of hemoglobin levels and was positively related to anemia. In addition to PS externalization, eryptosis of nRBC induced by
P. berghei
infection was characterized by cytoplasm calcium influx, but not caspases activity. These results confirm our previous studies evidencing a pro-eryptotic effect of malaria infection on nRBCs and show that a caspase-independent eryptotic process is implicated in anemia induced by
P. berghei
ANKA infection in Wistar rats. |
doi_str_mv | 10.1007/s00436-018-6167-1 |
format | Article |
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P. berghei
ANKA in Wistar rats, a malaria experimental model that, similar to human malaria, the infection courses with low parasitemia and acute anemia. As expected,
P. berghei
ANKA infection was marked by low parasite burdens that reached a mean peak of 3% between days six and nine post-infection and solved spontaneously. A significant reduction of the hemoglobin levels (~ 30%) was also observed on days subsequent to the peak of parasitemia, persisting until day 16 post-infection. In eryptosis assays, it was observed a significant increase in the levels of PS-exposing nRBC, which coincided with the reduction of hemoglobin levels and was positively related to anemia. In addition to PS externalization, eryptosis of nRBC induced by
P. berghei
infection was characterized by cytoplasm calcium influx, but not caspases activity. These results confirm our previous studies evidencing a pro-eryptotic effect of malaria infection on nRBCs and show that a caspase-independent eryptotic process is implicated in anemia induced by
P. berghei
ANKA infection in Wistar rats.</description><identifier>ISSN: 0932-0113</identifier><identifier>EISSN: 1432-1955</identifier><identifier>DOI: 10.1007/s00436-018-6167-1</identifier><identifier>PMID: 30506514</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Anemia ; Biomedical and Life Sciences ; Biomedicine ; Calcium influx ; Caspase ; Cytoplasm ; Erythrocytes ; Health aspects ; Hemoglobin ; Host-parasite relationships ; Immunology ; Immunology and Host-Parasite Interactions - Short Communication ; Infections ; Malaria ; Medical Microbiology ; Microbiology ; Observations ; Parasitemia ; Plasmodium (Protozoa) ; Red blood cells ; Rodents</subject><ispartof>Parasitology research (1987), 2019-01, Vol.118 (1), p.377-382</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>COPYRIGHT 2019 Springer</rights><rights>Copyright Springer Science & Business Media 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-b0834c9d1973c8769251f2e98c72e626e1d97437662aab3f44c8df2611dd16023</citedby><cites>FETCH-LOGICAL-c411t-b0834c9d1973c8769251f2e98c72e626e1d97437662aab3f44c8df2611dd16023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00436-018-6167-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00436-018-6167-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30506514$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Totino, Paulo Renato Rivas</creatorcontrib><creatorcontrib>de Souza, Hugo Amorim dos Santos</creatorcontrib><creatorcontrib>Correa, Edmar Henrique Costa</creatorcontrib><creatorcontrib>Daniel-Ribeiro, Cláudio Tadeu</creatorcontrib><creatorcontrib>Ferreira-da-Cruz, Maria de Fátima</creatorcontrib><title>Eryptosis of non-parasitized erythrocytes is related to anemia in Plasmodium berghei low parasitema malaria of Wistar rats</title><title>Parasitology research (1987)</title><addtitle>Parasitol Res</addtitle><addtitle>Parasitol Res</addtitle><description>It is known that premature elimination of non-parasitized RBCs (nRBCs) plays an important role in the pathogenesis of malarial anemia, in which suicidal death process (eryptosis) of nRBCs has been suggested to be involved. To check this possibility, we investigate eryptosis during infection of
P. berghei
ANKA in Wistar rats, a malaria experimental model that, similar to human malaria, the infection courses with low parasitemia and acute anemia. As expected,
P. berghei
ANKA infection was marked by low parasite burdens that reached a mean peak of 3% between days six and nine post-infection and solved spontaneously. A significant reduction of the hemoglobin levels (~ 30%) was also observed on days subsequent to the peak of parasitemia, persisting until day 16 post-infection. In eryptosis assays, it was observed a significant increase in the levels of PS-exposing nRBC, which coincided with the reduction of hemoglobin levels and was positively related to anemia. In addition to PS externalization, eryptosis of nRBC induced by
P. berghei
infection was characterized by cytoplasm calcium influx, but not caspases activity. These results confirm our previous studies evidencing a pro-eryptotic effect of malaria infection on nRBCs and show that a caspase-independent eryptotic process is implicated in anemia induced by
P. berghei
ANKA infection in Wistar rats.</description><subject>Anemia</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Calcium influx</subject><subject>Caspase</subject><subject>Cytoplasm</subject><subject>Erythrocytes</subject><subject>Health aspects</subject><subject>Hemoglobin</subject><subject>Host-parasite relationships</subject><subject>Immunology</subject><subject>Immunology and Host-Parasite Interactions - Short Communication</subject><subject>Infections</subject><subject>Malaria</subject><subject>Medical Microbiology</subject><subject>Microbiology</subject><subject>Observations</subject><subject>Parasitemia</subject><subject>Plasmodium (Protozoa)</subject><subject>Red blood cells</subject><subject>Rodents</subject><issn>0932-0113</issn><issn>1432-1955</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kUFv1DAQhS0EotuFH8AFWeLCJcVjO05yrKoClSrBAcTR8jqTraskXmxH1fbXM1UWkJCQD7bG37x59mPsDYgLEKL5kIXQylQC2sqAaSp4xjaglaygq-vnbCM6OgsAdcbOc74XAhqj9Ut2pkQtTA16wx6v0_FQYg6Zx4HPca4OLrkcSnjEnmM6lrsU_bFg5oQkHF2heonczTgFx8PMv44uT7EPy8R3mPZ3GPgYH_hJByfHJze6RDBN-BFycYknV_Ir9mJwY8bXp33Lvn-8_nb1ubr98unm6vK28hqgVDvRKu27HrpG-bYxnaxhkNi1vpFopEHou0arxhjp3E4NWvu2H6QB6HswQqote7_qHlL8uWAudgrZ4zjSE-KSrQTdCVlrqAl99w96H5c0kzuijFGmVdAQdbFSezeiDfMQS3KeVk9f4uOMQ6D6ZU1WpRYUyJbB2uBTzDnhYA8pTC4dLQj7lKRdk7SUpH1K0gL1vD1ZWXYT9n86fkdHgFyBTFfzHtNfr_9X_QVkAKif</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Totino, Paulo Renato Rivas</creator><creator>de Souza, Hugo Amorim dos Santos</creator><creator>Correa, Edmar Henrique Costa</creator><creator>Daniel-Ribeiro, Cláudio Tadeu</creator><creator>Ferreira-da-Cruz, Maria de Fátima</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190101</creationdate><title>Eryptosis of non-parasitized erythrocytes is related to anemia in Plasmodium berghei low parasitema malaria of Wistar rats</title><author>Totino, Paulo Renato Rivas ; de Souza, Hugo Amorim dos Santos ; Correa, Edmar Henrique Costa ; Daniel-Ribeiro, Cláudio Tadeu ; Ferreira-da-Cruz, Maria de Fátima</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-b0834c9d1973c8769251f2e98c72e626e1d97437662aab3f44c8df2611dd16023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Anemia</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Calcium influx</topic><topic>Caspase</topic><topic>Cytoplasm</topic><topic>Erythrocytes</topic><topic>Health aspects</topic><topic>Hemoglobin</topic><topic>Host-parasite relationships</topic><topic>Immunology</topic><topic>Immunology and Host-Parasite Interactions - Short Communication</topic><topic>Infections</topic><topic>Malaria</topic><topic>Medical Microbiology</topic><topic>Microbiology</topic><topic>Observations</topic><topic>Parasitemia</topic><topic>Plasmodium (Protozoa)</topic><topic>Red blood cells</topic><topic>Rodents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Totino, Paulo Renato Rivas</creatorcontrib><creatorcontrib>de Souza, Hugo Amorim dos Santos</creatorcontrib><creatorcontrib>Correa, Edmar Henrique Costa</creatorcontrib><creatorcontrib>Daniel-Ribeiro, Cláudio Tadeu</creatorcontrib><creatorcontrib>Ferreira-da-Cruz, Maria de Fátima</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Parasitology research (1987)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Totino, Paulo Renato Rivas</au><au>de Souza, Hugo Amorim dos Santos</au><au>Correa, Edmar Henrique Costa</au><au>Daniel-Ribeiro, Cláudio Tadeu</au><au>Ferreira-da-Cruz, Maria de Fátima</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Eryptosis of non-parasitized erythrocytes is related to anemia in Plasmodium berghei low parasitema malaria of Wistar rats</atitle><jtitle>Parasitology research (1987)</jtitle><stitle>Parasitol Res</stitle><addtitle>Parasitol Res</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>118</volume><issue>1</issue><spage>377</spage><epage>382</epage><pages>377-382</pages><issn>0932-0113</issn><eissn>1432-1955</eissn><abstract>It is known that premature elimination of non-parasitized RBCs (nRBCs) plays an important role in the pathogenesis of malarial anemia, in which suicidal death process (eryptosis) of nRBCs has been suggested to be involved. To check this possibility, we investigate eryptosis during infection of
P. berghei
ANKA in Wistar rats, a malaria experimental model that, similar to human malaria, the infection courses with low parasitemia and acute anemia. As expected,
P. berghei
ANKA infection was marked by low parasite burdens that reached a mean peak of 3% between days six and nine post-infection and solved spontaneously. A significant reduction of the hemoglobin levels (~ 30%) was also observed on days subsequent to the peak of parasitemia, persisting until day 16 post-infection. In eryptosis assays, it was observed a significant increase in the levels of PS-exposing nRBC, which coincided with the reduction of hemoglobin levels and was positively related to anemia. In addition to PS externalization, eryptosis of nRBC induced by
P. berghei
infection was characterized by cytoplasm calcium influx, but not caspases activity. These results confirm our previous studies evidencing a pro-eryptotic effect of malaria infection on nRBCs and show that a caspase-independent eryptotic process is implicated in anemia induced by
P. berghei
ANKA infection in Wistar rats.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30506514</pmid><doi>10.1007/s00436-018-6167-1</doi><tpages>6</tpages></addata></record> |
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subjects | Anemia Biomedical and Life Sciences Biomedicine Calcium influx Caspase Cytoplasm Erythrocytes Health aspects Hemoglobin Host-parasite relationships Immunology Immunology and Host-Parasite Interactions - Short Communication Infections Malaria Medical Microbiology Microbiology Observations Parasitemia Plasmodium (Protozoa) Red blood cells Rodents |
title | Eryptosis of non-parasitized erythrocytes is related to anemia in Plasmodium berghei low parasitema malaria of Wistar rats |
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