Succinylated Gelatin Improves the Theranostic Potential of Radiolabeled Exendin-4 in Insulinoma Patients

Being highly expressed in insulinomas, the glucagonlike peptide-1 receptor (GLP-1R) is a potential target for diagnosis, localization, and treatment with the radiolabeled GLP-1R agonist exendin. Tracer accumulation in the kidneys, however, hampers accurate diagnostic visualization of pancreatic tiss...

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Veröffentlicht in:	Journal of Nuclear Medicine 2019-06, Vol.60 (6), p.812-816
Hauptverfasser:	Buitinga, Mijke, Jansen, Tom, van der Kroon, Inge, Woliner-van der Weg, Wietske, Boss, Marti, Janssen, Marcel, Aarntzen, Erik, Béhé, Martin, Wild, Damian, Visser, Eric, Brom, Maarten, Gotthardt, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological Transport - drug effects Exenatide - metabolism Exenatide - therapeutic use Female Gelatin - pharmacology Humans Image Processing, Computer-Assisted Indium Radioisotopes - therapeutic use Insulinoma - diagnostic imaging Insulinoma - metabolism Insulinoma - radiotherapy Isotope Labeling Kidney - drug effects Kidney - metabolism Male Single Photon Emission Computed Tomography Computed Tomography Succinates - pharmacology
Online-Zugang:	Volltext
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