Therapeutic potential of ectopic olfactory and taste receptors
Olfactory and taste receptors are expressed primarily in the nasal olfactory epithelium and gustatory taste bud cells, where they transmit real-time sensory signals to the brain. However, they are also expressed in multiple extra-nasal and extra-oral tissues, being implicated in diverse biological p...
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| Veröffentlicht in: | Nature reviews. Drug discovery 2019-02, Vol.18 (2), p.116-138 |
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| creator | Lee, Sung-Joon Depoortere, Inge Hatt, Hanns |
| description | Olfactory and taste receptors are expressed primarily in the nasal olfactory epithelium and gustatory taste bud cells, where they transmit real-time sensory signals to the brain. However, they are also expressed in multiple extra-nasal and extra-oral tissues, being implicated in diverse biological processes including sperm chemotaxis, muscle regeneration, bronchoconstriction and bronchodilatation, inflammation, appetite regulation and energy metabolism. Elucidation of the physiological roles of these ectopic receptors is revealing potential therapeutic and diagnostic applications in conditions including wounds, hair loss, asthma, obesity and cancers. This Review outlines current understanding of the diverse functions of ectopic olfactory and taste receptors and assesses their potential to be therapeutically exploited.
Olfactory and taste receptors are ectopically expressed in multiple extra-nasal and extra-oral tissues, exhibiting potential functions in a diverse range of biological processes. Here, Lee et al. discuss the physiological roles of these ectopic olfactory and taste receptors, assessing their emerging therapeutic and diagnostic potential in conditions including asthma, wound healing, obesity and cancer. |
| doi_str_mv | 10.1038/s41573-018-0002-3 |
| format | Article |
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Olfactory and taste receptors are ectopically expressed in multiple extra-nasal and extra-oral tissues, exhibiting potential functions in a diverse range of biological processes. Here, Lee et al. discuss the physiological roles of these ectopic olfactory and taste receptors, assessing their emerging therapeutic and diagnostic potential in conditions including asthma, wound healing, obesity and cancer.</description><identifier>ISSN: 1474-1776</identifier><identifier>EISSN: 1474-1784</identifier><identifier>DOI: 10.1038/s41573-018-0002-3</identifier><identifier>PMID: 30504792</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/154 ; 631/378/2624/2625 ; 631/378/2626/2627 ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Biotechnology ; Bronchodilators ; Cancer ; Cancer Research ; Clinical trials ; Diabetes ; Endocrinology ; Fatty acids ; Humans ; Inflammatory bowel disease ; Insulin resistance ; Medicinal Chemistry ; Metabolites ; Microbiota ; Molecular Medicine ; Neural Pathways - physiology ; Olfactory Mucosa - innervation ; Olfactory Mucosa - physiology ; Olfactory Receptor Neurons - physiology ; Peptides ; Pharmacology/Toxicology ; Proteins ; Respiration ; Review Article ; Taste - physiology ; Taste Buds ; Trends</subject><ispartof>Nature reviews. Drug discovery, 2019-02, Vol.18 (2), p.116-138</ispartof><rights>Springer Nature Limited 2018</rights><rights>Copyright Nature Publishing Group Feb 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-76af64d1e72593abe93a4c8aa95c5f8fdbcff27216a37289af3cecff4ca240463</citedby><cites>FETCH-LOGICAL-c486t-76af64d1e72593abe93a4c8aa95c5f8fdbcff27216a37289af3cecff4ca240463</cites><orcidid>0000-0002-0661-5255</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41573-018-0002-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41573-018-0002-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30504792$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Sung-Joon</creatorcontrib><creatorcontrib>Depoortere, Inge</creatorcontrib><creatorcontrib>Hatt, Hanns</creatorcontrib><title>Therapeutic potential of ectopic olfactory and taste receptors</title><title>Nature reviews. Drug discovery</title><addtitle>Nat Rev Drug Discov</addtitle><addtitle>Nat Rev Drug Discov</addtitle><description>Olfactory and taste receptors are expressed primarily in the nasal olfactory epithelium and gustatory taste bud cells, where they transmit real-time sensory signals to the brain. However, they are also expressed in multiple extra-nasal and extra-oral tissues, being implicated in diverse biological processes including sperm chemotaxis, muscle regeneration, bronchoconstriction and bronchodilatation, inflammation, appetite regulation and energy metabolism. Elucidation of the physiological roles of these ectopic receptors is revealing potential therapeutic and diagnostic applications in conditions including wounds, hair loss, asthma, obesity and cancers. This Review outlines current understanding of the diverse functions of ectopic olfactory and taste receptors and assesses their potential to be therapeutically exploited.
Olfactory and taste receptors are ectopically expressed in multiple extra-nasal and extra-oral tissues, exhibiting potential functions in a diverse range of biological processes. Here, Lee et al. discuss the physiological roles of these ectopic olfactory and taste receptors, assessing their emerging therapeutic and diagnostic potential in conditions including asthma, wound healing, obesity and cancer.</description><subject>631/154</subject><subject>631/378/2624/2625</subject><subject>631/378/2626/2627</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Bronchodilators</subject><subject>Cancer</subject><subject>Cancer Research</subject><subject>Clinical trials</subject><subject>Diabetes</subject><subject>Endocrinology</subject><subject>Fatty acids</subject><subject>Humans</subject><subject>Inflammatory bowel disease</subject><subject>Insulin resistance</subject><subject>Medicinal Chemistry</subject><subject>Metabolites</subject><subject>Microbiota</subject><subject>Molecular Medicine</subject><subject>Neural Pathways - physiology</subject><subject>Olfactory Mucosa - innervation</subject><subject>Olfactory Mucosa - physiology</subject><subject>Olfactory Receptor Neurons - physiology</subject><subject>Peptides</subject><subject>Pharmacology/Toxicology</subject><subject>Proteins</subject><subject>Respiration</subject><subject>Review Article</subject><subject>Taste - physiology</subject><subject>Taste Buds</subject><subject>Trends</subject><issn>1474-1776</issn><issn>1474-1784</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kE1LAzEQhoMotlZ_gBdZ8OJlNV-7yV4EKX5BwUs9hzQ70S3bzZpkD_33pmytIHhJhjfPzIQHoUuCbwlm8i5wUgiWYyJzjDHN2RGaEi54ToTkx4dalBN0FsIaY1ISQU_RhOECc1HRKbpffoLXPQyxMVnvInSx0W3mbAYmuj6FrrU6lX6b6a7Oog4RMg8G-pSFc3RidRvgYn_P0PvT43L-ki_enl_nD4vccFnGXJTalrwmIGhRMb2CdHAjta4KU1hp65WxlgpKSs0ElZW2zECKuNGUY16yGboZ5_befQ0Qoto0wUDb6g7cEBQlvMIUMywTev0HXbvBd-l3iRLJSEHJjiIjZbwLwYNVvW822m8VwWonV41yVZKrdnIVSz1X-8nDagP1oePHZgLoCIT01H2A_139_9Rv_AOEUA</recordid><startdate>20190201</startdate><enddate>20190201</enddate><creator>Lee, Sung-Joon</creator><creator>Depoortere, Inge</creator><creator>Hatt, Hanns</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0661-5255</orcidid></search><sort><creationdate>20190201</creationdate><title>Therapeutic potential of ectopic olfactory and taste receptors</title><author>Lee, Sung-Joon ; Depoortere, Inge ; Hatt, Hanns</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-76af64d1e72593abe93a4c8aa95c5f8fdbcff27216a37289af3cecff4ca240463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>631/154</topic><topic>631/378/2624/2625</topic><topic>631/378/2626/2627</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Biotechnology</topic><topic>Bronchodilators</topic><topic>Cancer</topic><topic>Cancer Research</topic><topic>Clinical trials</topic><topic>Diabetes</topic><topic>Endocrinology</topic><topic>Fatty acids</topic><topic>Humans</topic><topic>Inflammatory bowel disease</topic><topic>Insulin resistance</topic><topic>Medicinal Chemistry</topic><topic>Metabolites</topic><topic>Microbiota</topic><topic>Molecular Medicine</topic><topic>Neural Pathways - physiology</topic><topic>Olfactory Mucosa - innervation</topic><topic>Olfactory Mucosa - physiology</topic><topic>Olfactory Receptor Neurons - physiology</topic><topic>Peptides</topic><topic>Pharmacology/Toxicology</topic><topic>Proteins</topic><topic>Respiration</topic><topic>Review Article</topic><topic>Taste - physiology</topic><topic>Taste Buds</topic><topic>Trends</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Sung-Joon</creatorcontrib><creatorcontrib>Depoortere, Inge</creatorcontrib><creatorcontrib>Hatt, Hanns</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Nature reviews. Drug discovery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Sung-Joon</au><au>Depoortere, Inge</au><au>Hatt, Hanns</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic potential of ectopic olfactory and taste receptors</atitle><jtitle>Nature reviews. Drug discovery</jtitle><stitle>Nat Rev Drug Discov</stitle><addtitle>Nat Rev Drug Discov</addtitle><date>2019-02-01</date><risdate>2019</risdate><volume>18</volume><issue>2</issue><spage>116</spage><epage>138</epage><pages>116-138</pages><issn>1474-1776</issn><eissn>1474-1784</eissn><abstract>Olfactory and taste receptors are expressed primarily in the nasal olfactory epithelium and gustatory taste bud cells, where they transmit real-time sensory signals to the brain. However, they are also expressed in multiple extra-nasal and extra-oral tissues, being implicated in diverse biological processes including sperm chemotaxis, muscle regeneration, bronchoconstriction and bronchodilatation, inflammation, appetite regulation and energy metabolism. Elucidation of the physiological roles of these ectopic receptors is revealing potential therapeutic and diagnostic applications in conditions including wounds, hair loss, asthma, obesity and cancers. This Review outlines current understanding of the diverse functions of ectopic olfactory and taste receptors and assesses their potential to be therapeutically exploited.
Olfactory and taste receptors are ectopically expressed in multiple extra-nasal and extra-oral tissues, exhibiting potential functions in a diverse range of biological processes. Here, Lee et al. discuss the physiological roles of these ectopic olfactory and taste receptors, assessing their emerging therapeutic and diagnostic potential in conditions including asthma, wound healing, obesity and cancer.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30504792</pmid><doi>10.1038/s41573-018-0002-3</doi><tpages>23</tpages><orcidid>https://orcid.org/0000-0002-0661-5255</orcidid></addata></record> |
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| subjects | 631/154 631/378/2624/2625 631/378/2626/2627 Animals Biomedical and Life Sciences Biomedicine Biotechnology Bronchodilators Cancer Cancer Research Clinical trials Diabetes Endocrinology Fatty acids Humans Inflammatory bowel disease Insulin resistance Medicinal Chemistry Metabolites Microbiota Molecular Medicine Neural Pathways - physiology Olfactory Mucosa - innervation Olfactory Mucosa - physiology Olfactory Receptor Neurons - physiology Peptides Pharmacology/Toxicology Proteins Respiration Review Article Taste - physiology Taste Buds Trends |
| title | Therapeutic potential of ectopic olfactory and taste receptors |
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