Influence of isostatic compression on the stability of vancomycin loaded with a calcium phosphate-implantable drug delivery device

It is essential to prevent microbial infections after osteoarticular trauma or prothesis implantation. As an alternative to antibiotic parenteral administration, antibiotic‐loaded biomaterials allow high concentrations to be obtained in situ without systemic toxicity. Although the formulation of bip...

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Veröffentlicht in:	Journal of biomedical materials research 2000-11, Vol.52 (2), p.308-314
Hauptverfasser:	Gautier, H., Caillon, J., Le Ray, A. M., Daculsi, G., Merle, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - chemistry Bioassay Biocompatible Materials Biological and medical sciences Biomaterials biphasic calcium phosphate Calcium compounds calcium phosphate Calcium Phosphates drug delivery device Drug Delivery Systems Extraction High pressure effects Humans isosatic compression Medical sciences Microbiology Postoperative Complications - prevention & control Prosthesis Implantation Spectrophotometry Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Toxicity ultraviolet and microbiologic assays vancomycin Vancomycin - administration & dosage Vancomycin - chemistry
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