A genetically-engineered polypeptide carrier for thermal targeting of therapeutics

A genetically-engineered polypeptide carrier for thermal targeting of therapeutics

Reports the synthesis of a environmentally-responsive polypeptide carrier for thermally-targeted delivery of radionuclide therapeutics. The authors hypothesized that systemically-injected radionuclide-polypeptide conjugates are likely to be cleared from circulation under physiological conditions, wh...

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Hauptverfasser: Meyer, D.E., Kong, G., Dewhirst, M., Chilkoti, A.
Format: Tagungsbericht
Sprache:eng
Schlagworte:
Biological information theory
Chemistry
Controlled drug delivery
Encoding
Genetic engineering
Medical treatment
Neoplasms
Phase transitions
Polymers
Polypeptides
Proteins
Radioisotopes
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creator Meyer, D.E.
Kong, G.
Dewhirst, M.
Chilkoti, A.
description Reports the synthesis of a environmentally-responsive polypeptide carrier for thermally-targeted delivery of radionuclide therapeutics. The authors hypothesized that systemically-injected radionuclide-polypeptide conjugates are likely to be cleared from circulation under physiological conditions, while externally-induced local hyperthermia at tumor sites will result in radionuclide accumulation because of carrier aggregation. The authors report preliminary in vivo results which support this hypothesis.
doi_str_mv 10.1109/IEMBS.1999.804458
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identifier ISSN: 1094-687X
ispartof Proceedings of the First Joint BMES/EMBS Conference : serving humanity advancing technology, Oct. 13-16, 99, Atlanta, GA, USA, 1999, Vol.2, p.1289 vol.2-1289
issn 1094-687X
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source IEEE Electronic Library (IEL) Conference Proceedings
subjects Biological information theory
Chemistry
Controlled drug delivery
Encoding
Genetic engineering
Medical treatment
Neoplasms
Phase transitions
Polymers
Polypeptides
Proteins
Radioisotopes
title A genetically-engineered polypeptide carrier for thermal targeting of therapeutics
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